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The TRAF1/C5 region is a risk factor for polyarthritis in Juvenile Idiopathic Arthritis.
  1. H M Albers (h.m.albers{at}lumc.nl)
  1. Leiden University Medical Center, Netherlands
    1. F AS Kurreeman (b.a.s.kurreeman{at}lumc.nl)
    1. Leiden University Medical Center, Netherlands
      1. J J Houwing-Duistermaat (j.j.houwing{at}lumc.nl)
      1. Leiden University Medical Center, Netherlands
        1. D MC Brinkman (d.m.c.brinkman{at}lumc.nl)
        1. Leiden University Medical Center, Netherlands
          1. S SM Kamphuis (s.kamphuis{at}erasmusmc.nl)
          1. Erasmus Medical Center- Sophia's Children Hospital, Netherlands
            1. H J Girschick (hermann.girschick{at}mail.uni-wuerzburg.de)
            1. University of Wuerzburg, Germany
              1. C Wouters (carine.wouters{at}uz.kuleuven.ac.be)
              1. University Hospital Gasthuisberg, Belgium
                1. M AJ Van Rossum (m.a.vanrossum{at}amc.uva.nl)
                1. Emma Children's Hospital AMC, Netherlands
                  1. W Verduyn (w.verduyn{at}lumc.nl)
                  1. Leiden University Medical Center, Netherlands
                    1. R EM Toes (r.e.m.toes{at}lumc.nl)
                    1. Leiden University Medical Center, Netherlands
                      1. T WJ Huizinga (t.w.j.huizinga{at}lumc.nl)
                      1. Leiden University Medical Center, Netherlands
                        1. M W Schilham (m.w.schilham{at}lumc.nl)
                        1. Leiden University Medical Center, Netherlands
                          1. R ten Cate (r.ten_cate{at}lumc.nl)
                          1. Leiden University Medical Center, Netherlands

                            Abstract

                            Objective: Juvenile Idiopathic Arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently we identified the TRAF1/C5 region (located on chromosome 9q33-34) as a risk factor for Rheumatoid Arthritis (RA) (pcombined= 1.4 x 10-8). In the present study the association of the TRAF1/C5 region with the susceptibility to JIA was investigated.

                            Methods: A case-control association study was performed in 338 Caucasian JIA patients and 511 healthy individuals. We genotyped SNP rs10818488 as a marker for the TRAF1/C5 region.

                            Results: The A-allele was associated with the susceptibility to Rheumatoid Factor (RF) negative polyarthritis with an 11% increase in allele frequency (OR 1.54, 95% CI 1.09- 2.18; p= 0.012). This association was stronger when combining subtypes with a polyarticular phenotype (OR 1.46, 95% CI 1.12- 1.90; p= 0.004). In addition, we observed a trend towards an increase in A-allele frequency in patients with extended oligoarthritis versus persistent oligoarthritis (49%, 38% respectively); p=0.055.

                            Conclusion: Apart from being a well replicated risk factor for RA, TRAF1/C5 also appears to be a risk factor for the RF negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterized by a polyarticular course.

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