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Familial aggregation of psoriatic arthritis
  1. Vinod Chandran (vinod.chandran{at}uhnres.utoronto.ca)
  1. Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Canada
    1. Catherine T Schentag (schentag{at}uhnres.utoronto.ca)
    1. Centre for Prognosis Studies in the Rheumatic Diseases, Canada
      1. John E. Brockbank (jbrockbank{at}tiscali.co.uk)
      1. Blackburn Royal Infirmary, United Kingdom
        1. Fawnda J Pellett (fpellett{at}uhnres.utoronto.ca)
        1. Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Canada
          1. Sutharshini Shanmugrajah (sshanmug{at}uhnres.utoronto.ca)
          1. Centre for Prognosis Studies in the Rheumatic Diseases, Canada
            1. Sergio M.A. Toloza (stoloza{at}uhnres.utoronto.ca)
            1. Centre for Prognosis Studies in the Rheumatic Diseases, Canada
              1. Proton Rahman (prahman{at}mun.ca)
              1. Memorial University of Newfoundland, Canada
                1. Dafna D Gladman (dafna.gladman{at}utoronto.ca)
                1. Centre for Prognosis Studies in the Rheumatic Diseases, Canada

                  Abstract

                  Objectives: To determine the recurrence risk of psoriatic arthritis (PsA) and uncomplicated psoriasis in first degree relatives (FDRs) of patients with PsA.

                  Methods: All available FDRs (full siblings, parents, and children) of 100 consecutive consenting patients attending a PsA clinic were evaluated for the presence of psoriasis and PsA using a standard protocol. The protocol included a screening questionnaire, physical examination by a rheumatologist, radiographic and laboratory assessment. Prevalence of PsA and Ps in FDRs of index case was determined and recurrence risk ratio λ was calculated, assuming a population prevalence of PsA of 0.25%, and population prevalence of Ps of 2%.

                  Results: The 100 probands had 533 relatives. Eighty four of them were deceased and 53 were unavailable (age <16 years). Of the remaining 396 FDRs, 107 did not participate (living too far away/did not consent). Thus, 289/396 (73%) of the available FDRs participated in the study. There were 130 siblings, 108 parents and 51 children. The prevalence of PsA and psoriasis among FDRs was 7.6% and 15.2%, respectively. The λ1 was 30.4 for PsA and 7.6 for Ps. The prevalence of PsA and psoriasis in siblings was 7.7% and 17.7%, respectively. The λS was 30.8 for PsA and 8.8 for Ps.

                  Conclusions: The recurrence risk ratio for both PsA and psoriasis is high in FDRs and siblings of patients with PsA. These results confirm that both PsA and psoriasis have a strong heritable component.

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