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Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis
  1. Sudha Visvanathan (svisvana{at}cntus.jnj.com)
  1. Centocor Research and Development, Inc., United States
    1. Désireé van der Heijde
    1. University Hospital Maastricht, Netherlands
      1. Atul Deodhar
      1. Oregon Health and Science University, United States
        1. Carrie Wagner
        1. Centocor Research and Development, Inc., United States
          1. Daniel G Baker
          1. Centocor Research and Development, Inc., United States
            1. John Han
            1. Centocor Research and Development, Inc., United States
              1. Jürgen Braun
              1. Rheumazentrum Ruhrgebiet, Germany

                Abstract

                Objectives: To evaluate the relationship between bone mineral density (BMD) and biomarkers of bone turnover and inflammation in patients with ankylosing spondylitis (AS) treated with infliximab.

                Methods: Patients (n=279) were randomly assigned (3:8) to receive placebo or 5 mg/kg infliximab every 6 weeks through week 96. At week 24, placebo-treated patients crossed over to infliximab 5 mg/kg. Starting at week 36, infliximab-treated patients received dose escalations to 7.5 mg/kg. Hip and spine BMD were measured (baseline, week 24, week 102) using dual-energy x-ray absorptiometry. Sera were analyzed (baseline, week 24, week 102) for levels of bone alkaline phosphatase (BAP), osteocalcin, C-terminal crosslinking telopeptide of type I collagen (CTX), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and transforming growth factor-β.

                Results: Infliximab-treated patients showed significantly greater median increases in BMD of the spine (2.5%, p<0.001) and hip (0.5%, p=0.033) at week 24 than those who received placebo (0.5% and 0.2%, respectively). Baseline levels of IL-6, VEGF, osteocalcin, BAP, and CTX were significantly correlated with increases in spinal BMD at weeks 24 and 102 in the infliximab group. In a multiple regression analysis, high baseline osteocalcin levels and early increases in BAP at week 2 were significantly associated with increases in BMD scores of the spine (week 102) and hip (weeks 24 and 102) in the infliximab group.

                Conclusions: Patients with AS who received infliximab showed significant increases in BMD scores over 2 years. While many significant correlations were observed between BMD scores of the hip and spine and biomarker levels, high baseline osteocalcin levels and early increases in BAP were consistently associated with increases in BMD scores.

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