Article Text

other Versions

PDF
The BLyS/BAFF receptor-ligand system in HCV induced B-cell clonal disorders
  1. Dan-Avi Landau (dan.landau{at}yale.edu)
  1. Centre National de la Recherche Sientifique/Universite Pierre et Marrie Curie, France
    1. Michelle Rosenzwajg (michelle.rosenzwajg{at}chups.jussieu.fr)
    1. Centre National de la Recherche Sientifique/Universite Pierre et Marrie Curie, France
      1. David Saadoun (dsaadoun{at}wanadoo.fr)
      1. Hopital La Pitie Salpetriere, France
        1. David Klatzmann (kd54{at}mac.com)
        1. Centre National de la Recherche Sientifique/Universite Pierre et Marrie Curie, France
          1. Patrice Cacoub (patrice.cacoub{at}psl.aphp.fr)
          1. Hopital La Pitie Salpetriere, France

            Abstract

            Objective: The study aim was to examine the B-Lymphocytes Stimulator (BLyS) receptor-ligand system in HCV induced B lymphocyte clonal disorders.

            Methods: Ninety four patients with chronic HCV [including 35 HCV+ mixed cryoglobulinemia (MC)-vasculitis and 9 HCV+ B-non Hodgkin’s lymphoma (B-NHL) patients] and 15 healthy volunteers were included.

            Results: A 2-fold serum BLyS increase was associated with HCV-induced MC-vasculitis, and a three-fold increase with HCV-induced B-NHL, compared with HCV+ patients without vasculitis or healthy controls (p<0.05). Lower membrane BLyS expression in HCV-induced MC vasculitis was observed. CD19+ BLyS binding and BR3 staining showed a step wise decrease with highest values in healthy controls and HCV+ without MC, and lowest in B-NHL (p<0.05, p<0.0001, respectively) with a further decrease in Vh1-69+ clonal B-cells. BLyS anti-apoptotic effects were maintained despite this decrease in BR3 staining. Complete clinical remission after anti-viral treatment was associated with a decrease in serum BLyS, and an increase in BR3 staining. Rituximab treatment was associated with a five-fold increase in serum BLyS (p<0.001), mirroring the depletion of CD19+ cells. BR3 staining in repopulating B-cells was significantly decreased (p<0.005).

            Conclusion: the BLyS ligand-receptor activity is increased in HCV induced B-cell clonal disorders, indicating a possible role for treatment targeting the BLyS receptor-ligand system.

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.