The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders

Abstract

Objectives: Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) affect a relatively large portion of the population, leading to severe disability if left untreated. Even though pharmaceutics targeting the immune system have revolutionized the therapy of these diseases, there is still a need for novel, more effective therapeutic substances. One such substance is the new chemical entity 9-chloro-2,3 dimethyl-6-(N,N-dimthylamino-2-oxoethyl)-6H-indolo [2,3-b] quionoxaline, Rabeximod, that is currently being investigated for efficiency in treatment of human RA. In this study we aimed to evaluate Rabeximod as a treatment for autoimmune diseases, using animal models.

Methods: In the present investigation we have evaluated Rabeximod as a treatment for autoimmune diseases using mouse models of RA and MS, i.e. collagen-induced arthritis, collagen antibody induced arthritis and experimental autoimmune encephalomyelitis.

Results: Rabeximod efficiently prevented both arthritis and encephalomyelitis in mice. In addition, this effect correlated to the time-point when cells migrate into the joints.

Conclusions: We conclude that Rabeximod reduces disease severity in animal models of autoimmunity and should be considered as a new therapeutic substance for MS and RA.