Article Text

other Versions

PDF
Knee alignment differences between Chinese and Caucasians subjects without osteoarthritis
  1. William F Harvey (william.harvey{at}bmc.org)
  1. Boston University Clinical Epidemiology Research and Training Unit, United States
    1. Jingbo Niu (niujp{at}bu.edu)
    1. Boston University Clinical Epidemiology Research and Training Unit, United States
      1. Yuqing Zhang (yuqing{at}bu.edu)
      1. Boston University Clinical Epidemiology Research and Training Unit, United States
        1. Paula I McCree (pmccree{at}bu.edu)
        1. Boston University Clinical Epidemiology Research and Training Unit, United States
          1. David T Felson (dfelson{at}bu.edu)
          1. Boston University Clinical Epidemiology Research and Training Unit, United States
            1. Michael C. Nevitt (mnevitt{at}psg.ucsf.edu)
            1. University of California, San Francisco, United States
              1. Ling Xu (xuling{at}csc.pumch.ac.cn)
              1. PUMC Hospital, China
                1. Piran Aliabadi (paliabadi{at}partners.org)
                1. Brigham and Women's Hospital, United States
                  1. David J Hunter (djhunter{at}bu.edu)
                  1. Boston University Clinical Epidemiology Research and Training Unit, United States

                    Abstract

                    Objective: Despite lower prevalence of obesity, a known risk factor for osteoarthritis (OA), the prevalence of lateral tibiofemoral (LTF) OA is higher in Chinese communities compared with Caucasian communities. One potential explanation is difference in knee alignment between the two populations. We measured various knee alignment indices among Chinese and Caucasians and assessed whether these indices were different between two racial groups.

                    Methods: We selected participants from the Framingham Osteoarthritis Study (FOA) and the Beijing Osteoarthritis Study (BOA), all without knee OA (K&L<2). Bilateral, fully extended AP knee radiographs were measured for the following angles in both knees: the anatomic axis (AA), the condylar angle (CA), the tibial plateau angle (PA) and the condylar-plateau angle (CP). We compared the mean of each measurement between the two racial groups adjusting for age and BMI using linear regression and stratified by sex.

                    Results: The mean AA, CA, and CP were significantly different in BOA compared with FOA. For women, the mean AA and CA were significantly more valgus in BOA subjects, while in men, the mean AA and CP were more valgus in BOA subjects.

                    Conclusions: There are significant differences in knee morphology between Chinese and Caucasian cohorts which result in a more valgus alignment of the distal femur in Chinese. This would serve to shift the mechanical loading towards the lateral compartment, and provide a possible explanation why Chinese have a higher prevalence of LTF OA.

                    • alignment
                    • biomechanics
                    • epidemiology
                    • knee
                    • osteoarthritis

                    Statistics from Altmetric.com

                    Request permissions

                    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.