Background and objectives: The Fc receptor-like 3 (FCRL3) -169T>C single nucleotide polymorphism (SNP) has been reported associated with several autoimmune diseases (AIDs) in Japanese populations. However, association results in other populations have been conflicting. Therefore, we have investigated this SNP in a Scandinavian panel of AIDs.
Methods: We genotyped patients with rheumatoid arthritis (RA; n=708), juvenile idiopathic arthritis (JIA; n=524), systemic lupus erythematosus (SLE; n=166), ulcerative colitis (UC; n=335), primary sclerosing cholangitis (PSC; n=365), Crohn’s disease (CD; n=149), a healthy control group (n=1030) and 425 trio families with type 1 diabetes (T1D). Statistical analysis consisted of both case-control and family-based association tests.
Results: RA was associated both with the C allele (OR=1.16, 95 % CI 1.01-1.33) and the CC genotype (OR=1.30, 95 % CI 1.01-1.67) of the FCRL3 -169T>C SNP in our material. Suggestive evidence for association was also found for JIA (CC genotype: OR=1.30, 95% CI 0.99-1.70), and clinical subgroup analysis indicated that this was connected to the polyarticular subgroup. No significant association was found with SLE, UC, CD, PSC or T1D. In RA patients, we found no significant interaction between the FCRL3 -169T>C and PTPN22 1858C>T SNPs, nor between the FCRL3 -169CC genotype and IgM-rheumatoid factor or anti-cyclic citrullinated peptide titer levels.
Conclusion: We found an association between the FCRL3 -169T>C SNP and RA, and suggestive evidence for involvement with JIA, in a Norwegian population. These findings lend support for a role for this SNP in RA across ethnically diverse populations, and warrant follow-up studies in JIA.
- genetic predisposition
- juvenile idiopathic arthritis
- rheumatoid arthritis