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A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic Gout
  1. William J Taylor (will.taylor{at}otago.ac.nz)
  1. University of Otago Wellington, New Zealand
    1. H. Ralph Schumacher, Jr (schumacr{at}mail.med.upenn.edu)
    1. VA Medical Center, University of Pennsylvania, United States
      1. Herbert S.B. Baraf (hsbbaraf{at}mac.com)
      1. George Washington University, United States
        1. Peter Chapman (peter.chapman{at}cdhb.govt.nz)
        1. Canterbury District Health Board, Christchurch, New Zealand
          1. Lisa Stamp (lisa.stamp{at}cdhb.govt.nz)
          1. University of Otago Christchurch, New Zealand
            1. Michael Doherty (michael.doherty{at}nottingham.ac.uk)
            1. City Hospital, Nottingham, United Kingdom
              1. Fiona M. McQueen (f.mcqueen{at}auckland.ac.nz)
              1. Auckland University, New Zealand
                1. Nicola Dalbeth (n.dalbeth{at}auckland.ac.nz)
                1. University of Auckland, New Zealand
                  1. Naomi Schlesinger (schlesna{at}umdnj.edu)
                  1. University of New Jersey, United States
                    1. Daniel E Furst (defurst{at}mednet.ucla.edu)
                    1. Univ of California at Los Angeles, United States
                      1. Janitzia Vazquez Mellado (jvazquezmellado{at}gmail.com)
                      1. Hospital General de Mexico, Mexico
                        1. Michael A Becker (mbecker{at}medicine.bsd.uchicago.edu)
                        1. University of Chicago, United States
                          1. Arthur Kavanaugh (akavanaugh{at}ucsd.edu)
                          1. University of California at San Diego, United States
                            1. Worawit Louthrenoo (wlouthre{at}mail.med.cmu.ac.th)
                            1. Chiang Mai University, Thailand
                              1. Thomas Bardin (thomas.bardin{at}lrb.ap-hop-paris.fr)
                              1. Hôpital Lariboisière, France
                                1. Dinesh Khanna (dkhanna{at}mednet.ucla.edu)
                                1. University of California at Los Angeles, United States
                                  1. Lee S Simon (lsimon{at}bidmc.harvard.edu)
                                  1. Harvard Medical School, United States
                                    1. Hisashi Yamanaka (yamanaka{at}ior.twmu.ac.jp)
                                    1. Tokyo Women's Medical University, Japan
                                      1. Hyon K Choi (hchoi{at}partners.org)
                                      1. University of British Columbia, United States
                                        1. Xuejun Zeng (zxuejun{at}yahoo.com)
                                        1. Peking Union Medical College Hospital, China
                                          1. Vibeke Strand (vstrand{at}aol.com)
                                          1. Stanford University, United States
                                            1. Rebecca Grainger (rgrainger{at}malaghan.org.nz)
                                            1. University of Otago Wellington, New Zealand
                                              1. Daniel Clegg (daniel.clegg{at}hsc.utah.edu)
                                              1. University of Utah, United States
                                                1. Jasvinder A Singh (jasvinder.singh{at}va.gov)
                                                1. Minneapolis Veterans Affairs Medical Center, New Zealand
                                                  1. Cesar Diaz-Torne (cesardiaztorne{at}gmail.com)
                                                  1. Hospital de la Santa Creu i Sant Pau, Spain
                                                    1. Maarten Boers (mboers56{at}xs4all.nl)
                                                    1. VU University Medical Center, Netherlands
                                                      1. Peter Gow (pgow{at}middlemore.co.nz)
                                                      1. Counties-Manukau District Health Board, New Zealand
                                                        1. Victoria Barskova (barskova{at}irramn.ru)
                                                        1. Russian Academy of Medical Sciences, Russian Federation

                                                          Abstract

                                                          Objectives: To reach consensus with recommendations made by an OMERACT Special Interest Group (SIG).

                                                          Methods: Rheumatologists and industry representatives interested in gout rated and clarified, in 3 iterations, the importance of domains proposed by the OMERACT SIG for use in acute and chronic gout intervention studies. Consensus was defined as a value of less than 1 of the UCLA/RAND disagreement index.

                                                          Results: There were 33 respondents (61% response rate); all agreed the initial items were necessary, except ‘total body urate pool’. Additional domains were suggested and clarification sought for defining ‘joint inflammation’ and ‘musculoskeletal function’. Items that demonstrated no clear decision were re-rated in the final iteration. There were 6 highly rated items (rating 1-2) with 4 slightly lower rating items (rating 3) for acute gout; and 11 highly rated items with 8 slightly lower ratings for chronic gout.

                                                          Conclusion: Consensus is that the following domains be considered mandatory for acute gout studies: pain, joint swelling, joint tenderness, patient global, physician global, functional disability; and for chronic gout studies: serum urate, gout flares, tophus regression, HRQOL, functional disability, pain, patient global, physician global, work disability and joint inflammation. Several additional domains were considered discretionary.

                                                          • Delphi
                                                          • Gout
                                                          • OMERACT
                                                          • expert consensus
                                                          • outcome measures

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