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Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive CRP levels in the GARP study.
  1. S D Bos (s.bos{at}lumc.nl)
  1. Leiden University Medical Center, Netherlands
    1. H ED Suchiman (h.e.d.suchiman{at}lumc.nl)
    1. Leiden University Medical Center, Netherlands
      1. M Kloppenburg (g.kloppenburg{at}lumc.nl)
      1. LUMC, Netherlands
        1. J J Houwing-Duistermaat (j.j.houwing{at}lumc.nl)
        1. LUMC, Netherlands
          1. M-P Hellio Le Graverand (helliomp{at}pfizer.com)
          1. Pfizer Global Research & Development, United States
            1. A B Seymour (albert.b.seymour{at}pfizer.com)
            1. Pfizer Global Research & Development, United States
              1. H M Kroon (h.m.j.a.kroon{at}lumc.nl)
              1. Leiden University Medical Center, Netherlands
                1. P E Slagboom (p.slagboom{at}lumc.nl)
                1. Leiden University Medical Center, Netherlands
                  1. I Meulenbelt (i.meulenbelt{at}lumc.nl)
                  1. Leiden University Medical Center, Netherlands

                    Abstract

                    Objective: To gain more insight in the role of genetic variation at the C-reactive protein (CRP) gene in serum CRP levels and osteoarthritis (OA).

                    Methods: Serum high sensitive CRP (S-HsCRP) levels were measured in the Genetics of osteoARthritis and Progression (GARP) study . Furthermore, to assess genetic variation at the CRP gene, genotypes of 5 tagging SNPs were assessed in the GARP study and a random control sample.

                    Results: A significant and consistent relation between S-HsCRP levels and observed haplotypes was identified. Additionally, a CRP haplotype, which also associated to a significant higher expected phenotypic mean S-HsCRP level, was associated to severe hand OA. This haplotype was tagged by a single SNP (rs3091244). Carriers of this allele have an increased risk for the presence of severe hand OA with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009).

                    Conclusion: A haplotype of the CRP gene, associated to high basal S-HsCRP level, is also associated to hand OA severity, indicating that innate high basal S-HsCRP levels may influence OA onset.

                    • C-reactive protein
                    • haplotypes
                    • osteoarthritis

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