Objective: To gain more insight in the role of genetic variation at the C-reactive protein (CRP) gene in serum CRP levels and osteoarthritis (OA).
Methods: Serum high sensitive CRP (S-HsCRP) levels were measured in the Genetics of osteoARthritis and Progression (GARP) study . Furthermore, to assess genetic variation at the CRP gene, genotypes of 5 tagging SNPs were assessed in the GARP study and a random control sample.
Results: A significant and consistent relation between S-HsCRP levels and observed haplotypes was identified. Additionally, a CRP haplotype, which also associated to a significant higher expected phenotypic mean S-HsCRP level, was associated to severe hand OA. This haplotype was tagged by a single SNP (rs3091244). Carriers of this allele have an increased risk for the presence of severe hand OA with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009).
Conclusion: A haplotype of the CRP gene, associated to high basal S-HsCRP level, is also associated to hand OA severity, indicating that innate high basal S-HsCRP levels may influence OA onset.
- C-reactive protein