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Dynamic contrast enhanced MRI of bone marrow oedema in rheumatoid arthritis.
  1. Richard Hodgson (richardhodgson{at}btinternet.com)
  1. University of Liverpool, United Kingdom
    1. Andrew Grainger (richardhodgson{at}btinternet.com)
    1. Chapel Allerton Hospital, United Kingdom
      1. Philip O'Connor (richardhodgson{at}btinternet.com)
      1. Chapel Allerton Hospital, United Kingdom
        1. Theresa Barnes (richardhodgson{at}btinternet.com)
        1. University of Liverpool, United Kingdom
          1. Sylvia Connolly (richardhodgson{at}btinternet.com)
          1. Whiston Hospital, United Kingdom
            1. Robert Moots (richardhodgson{at}btinternet.com)
            1. University of Liverpool, United Kingdom

              Abstract

              Aims: The aim of this work was to assess the feasibility of using Dynamic Contrast Enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems and to determine the effects of anti-TNFα therapy.

              Methods: The wrist and MCP joints of 25 patients with rheumatoid arthritis were studied. 14 were imaged before and 1-2 weeks after anti-TNFα therapy. T2 weighted fat suppressed images were collected. A dynamic series of 24 3D spoiled gradient echo images were acquired before, during and after the intravenous administration of gadolinium based contrast medium. Oedema was scored using the conventional Rheumatoid Arthritis MRI Score (RAMRIS) from T2 weighted images. The Relative Enhancement Rate (RER) was calculated using the dynamic series from oedematous bone, bone adjacent to oedema and from an uninvolved bone.

              Results 56% of patients showed bone marrow oedema. The RER was significantly increased in and adjacent to areas of marrow oedema. There was a significant reduction in the RER after treatment, but not in the RAMRIS score.

              Conclusions: Dynamic contrast enhanced MRI of bone marrow oedema yields additional information to RAMRIS scoring and may be a more sensitive marker of inflammatory activity and response to treatment.

              • MRI
              • RA
              • TNF blockers
              • bone marrow oedema
              • dynamic contrast enhanced MRI

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