Article Text

other Versions

PDF
B cell depletion therapy for patients with systemic lupus erythematosus results in a significant drop in anticardiolipin antibody titres.
  1. Yiannis Ioannou (j.ioannou{at}ich.ucl.ac.uk)
  1. University College London, United Kingdom
    1. Anastasia Lambrianides (n.lambrianides{at}ich.ucl.ac.uk)
    1. University College London, United Kingdom
      1. Geraldine Cambridge (g.cambridge{at}ucl.ac.uk)
      1. University College London, United Kingdom
        1. Maria J Leandro (maria.leandro{at}ucl.ac.uk)
        1. University College London, United Kingdom
          1. Jonathan CW Edwards (jo.edwards{at}ucl.ac.uk)
          1. University College London, United Kingdom
            1. David A Isenberg (d.isenberg{at}ucl.ac.uk)
            1. University College London, United Kingdom

              Abstract

              B cell depletion therapy (BCDT) has recently been used with success to treat patients with rheumatoid arthritis and SLE. As antiphospholipid antibodies have been implicated in the pathogenesis of the antiphospholipid syndrome (APS), we asked the question whether BCDT affects levels of IgG anticardiolipin antibodies (aCL) in our cohort of 32 SLE patients given this treatment. We identified seven SLE patients who had undergone BCDT and had had at least two moderate positive aCL titres at least 12 weeks apart. Of these only one patient had the APS. IgG aCL were measured at time 0 and 6-9 months post BCDT. At time 0, the mean IgG aCL level was 20.6 GPLU (range 10-32, SD 10.1, normal<5). At 6-9 months post depletion the IgG aCL levels in six of the seven patients was undetectable and in the other patient the level reduced from 25 GPLU to 15 GPLU (p<0.005, 2-tailed paired t-test). At baseline, only one patient had a mildly positive anti-ß2GPI antibody level at 30% (compared to an in-house standard), which fell to 5% post-BCDT. This small observational study in patients with SLE is the first to demonstrate that BCDT results in a significant reduction in levels of IgG aCL.

              • B cell
              • anticardiolipin
              • antiphospholipid
              • depletion
              • rituximab

              Statistics from Altmetric.com

              Request permissions

              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.