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Prevalence of Sjogren's syndrome among Nagasaki atomic bomb survivors
  1. Ayumi Hida (ayumih{at}rerf.or.jp)
  1. Radiation Effects Research Foundation, Japan
    1. Masazumi Akahoshi
    1. Radiation Effects Research Foundation, Japan
      1. Yukinori Takagi
      1. Nagasaki University School of Dentistry, Japan
        1. Kiyoto Ashizawa
        1. Radiation Effects Research Foundation, Japan
          1. Misa Imaizumi
          1. Radiation Effects Research Foundation, Japan
            1. Midori Soda
            1. Radiation Effects Research Foundation, Japan
              1. Renju Maeda
              1. Radiation Effects Research Foundation, Japan
                1. Eiji Nakashima
                1. Radiation Effects Research Foundation, Japan
                  1. Hiroaki Ida
                  1. Graduate School of Biomedical Sciences, Nagasaki University, Japan
                    1. Atsushi Kawakami (atsushik{at}net.nagasaki-u.ac.jp)
                    1. Graduate School of Biomedical Sciences, Nagasaki University, Japan
                      1. Takashi Nakamura
                      1. Nagasaki University School of Dentistry, Japan
                        1. Katsumi Eguchi
                        1. Graduate School of Biomedical Sciences, Nagasaki University, Japan

                          Abstract

                          Objectives: Through a comprehensive epidemiological study, we determined Sjögren’s syndrome (SS) prevalence and examined the association between SS and ionizing radiation dose.

                          Methods: A total of 1,008 atomic bomb survivors in Nagasaki agreed to undergo the tests comprising questionnaire for xerophthalmia and xerostomia, Schirmer-I test, Saxon test, and tests of anti-SS-A/Ro and anti-SS-B/La antibodies, and, if necessary, Rose Bengal stain test, salivary ultrasonographic and MRI examination from November 2002 through October 2004. Diagnosis of SS was based on the American-European Consensus Group criteria, or a modified one.

                          Results: Among the 1008 participants (male 398, female 610, average age 71.6 years), 154 participants (15.3%) complained of xerophthalmia, and 264 (26.2%) of xerostomia. Reduced tear flow by the Schirmer-I test was detected in 371 of 992 participants (37.4%) and reduced saliva flow by the Saxon test in 203 of 993 participants (20.4%). Among all participants, 38 (3.8%) and 10 (1.0%) participants tested positive for anti-SS-A/Ro and anti-SS-B/La antibodies, respectively. Taking into consideration all the results, 23 participants were diagnosed with SS (primary 20, secondary 3), yielding a prevalence of 2.3%. Although the association between SS and radiation dose was not significant, radiation dose was significantly associated with hyposalivation.

                          Conclusions: The present comprehensive epidemiological study revealed that the prevalence of SS was 2.3% among Nagasaki atomic bomb survivors and was not associated with radiation dose. The association between radiation dose and hyposalivation supported the possibility that radiation exposure damaged salivary gland function.

                          • Japan
                          • Sjogren's syndrome
                          • prevalence
                          • radiation
                          • sicca syndrome

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