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EULAR evidence based recommendations for the management of fibromyalgia syndrome
  1. S F Carville (serena.carville{at}
  1. King's College London, United Kingdom
    1. S Arendt-Nielsen (lan{at}
    1. Aalborg University, Denmark
      1. H Bliddal (hb{at}
      1. The Parker Institute, Frederiksberg Hospital, Denmark
        1. F Blotman (f-blotman{at}
        1. Hospital Lapyeronie, France
          1. J C Branco (jaimeb.med2{at}
          1. Hospital Egas Moniz, Portugal
            1. D Buskilla (dbuskila{at}
            1. Soroka Medical Center, Israel
              1. J AP Da Silva (jdasilva{at}
              1. Hopitais Da Universidade, Portugal
                1. B Danneskiold-Samsøe (bente.danneskiold{at}
                1. The Parker Institute, Frederiksberg Hospital, Denmark
                  1. F Dincer (fitnatdincer{at}
                  1. Hacettepe Medical School, Turkey
                    1. C Henriksson (chris.henriksson{at}
                    1. INR, Linkoping University, Sweden
                      1. K Henriksson (karl-g{at}
                      1. University Hospital Linkoping, Sweden
                        1. E Kosek (eva.kosek{at}
                        1. Karolinska Institute, Sweden
                          1. K Longley (kathy_fibro{at}
                          1. Bath, United Kingdom
                            1. G M McCarthy (gmccarthy{at}
                            1. Mater Misericordiae University Hospital, Republic of Ireland
                              1. S Perrot (serge.perrot{at}
                              1. Hospital Cochin,, France
                                1. M J Puszczewicz (puszczewicz{at}
                                1. Rehabilitation and Internal Medicine University of Medical Sciences, Poland
                                  1. P Sarzi-Puttini (sarzi{at}
                                  1. Sacco University Hospital, Italy
                                    1. A Silman (alan.silman{at}
                                    1. University of Manchester, United Kingdom
                                      1. M Späth (spaeth.m5{at}
                                      1. University of Munich, Germany
                                        1. E H Choy (ernest.choy{at}
                                        1. King's College London, United Kingdom


                                          Objective: To develop evidence based recommendations for the management of fibromyalgia syndrome (FMS).

                                          Methods: A multidisciplinary task force was formed representing eleven European Countries. The design of the study including search strategy, participants, interventions, outcome measures, data collection and analytical method was defined at the outset. A systematic review was undertaken with the keywords ‘fibromyalgia’, ‘treatment or management’ and ‘trial’. Studies were excluded if they did not utilise the ACR classification criteria, were not clinical trials, or included patients with chronic fatigue syndrome or myalgic encephalomyelitis. Primary outcome measures were change in pain assessed by visual analogue scale (VAS) and fibromyalgia impact questionnaire (FIQ). The quality of the studies was categorised based on randomisation, blinding and allocation concealment. Only the highest quality studies were used to base recommendations on. When there was insufficient evidence from the literature, a Delphi process was used to provide basis for recommendation.

                                          Results: One hundred and forty six studies were eligible for the review. Thirty nine pharmacologic intervention studies and 59 non-pharmacologic were included in the final recommendation summary tables once those of a lower quality or with insufficient data were separated. The categories of treatment identified were antidepressants, analgesics, and ‘other pharmacological’ and exercise, cognitive behavioural therapy, education, dietary interventions and ‘other non-pharmacological’. In many studies sample size was small and the quality of the study was insufficient for strong recommendations to be made.

                                          Conclusion: Nine recommendations for the management of FMS were developed using a systematic review and expert consensus.

                                          • EULAR
                                          • Fibromyalgia
                                          • Management
                                          • Systematic review

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                                            BMJ Publishing Group Ltd and European League Against Rheumatism