Article Text

other Versions

PDF
Correlation between bone lesion changes and cartilage volume loss in knee osteoarthritis patients as assessed by quantitative MRI over a 24 month period
  1. J-P Raynauld (jp.raynauld{at}videotron.ca)
  1. Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Canada
    1. J Martel-Pelletier (jm{at}martelpelletier.ca)
    1. Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Canada
      1. M-J Berthiaume (mjberthiaume{at}videotron.ca)
      1. Department of Radiology, Maisonneuve-Rosemont Hospital, Canada
        1. F Abram (fabram{at}arthrovision.biz)
        1. ArthroVision, Canada
          1. D Choquette (denis.choquette.irm{at}videotron.ca)
          1. Department of Medicine, University of Montreal, Canada
            1. B Haraoui (boulos.haraoui{at}ssss.gouv.qc.ca)
            1. Department of Medicine, University of Montreal, Canada
              1. J F Beary (beary.jf{at}pg.com)
              1. Procter & Gamble Pharmaceuticals, United States
                1. G A Cline (cline.ga{at}pg.com)
                1. Procter & Gamble Pharmaceuticals, United States
                  1. J M Meyer (meyer.jm{at}pg.com)
                  1. Procter & Gamble Pharmaceuticals, United States
                    1. J-P Pelletier (dr{at}jppelletier.ca)
                    1. Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Canada

                      Abstract

                      Objective: To evaluate in knee osteoarthritis (OA) patients the size changes in bone edema and cysts over 24 months, and to contrast these changes with cartilage volume loss using quantitative MRI.

                      Methods: 107 knee OA patients, selected from a large trial evaluating the effect of a bisphosphonate, were analyzed by MRI at baseline and 24 months. Assessments of subchondral bone edema and cysts, and cartilage volume were done.

                      Results: At baseline, 86 patients showed the presence of at least one type of bone lesion: 71 edema, 61 cysts and 51 both. At 24 months, although not statistically significant, the edema total size change increased by 2.09 ± 15.03 mm, and the cyst by 1.09 ± 8.13 mm; mean size change for the edema was +0.38 ± 2.18 mm and -0.10 ± 4.36 mm for the cyst. When analyzed according to subregions, an increase was found for the cyst size in the trochlea (+0.67 ± 2.74 mm, p=0.02) and in the lateral tibial plateau (+0.15 ± 0.83 mm, p=0.09), and for the edema size in the medial tibial plateau (+1.73 ± 8.11 mm, p=0.05). At 24 months, significant correlations were seen between the loss of cartilage volume and edema size change in the medial condyle (-0.40, p=0.0001) and the medial tibial plateau (-0.23, p=0.03), and the changes in cyst size in the medial condyle (-0.29, p=0.01). A multivariate analysis showed that the edema size change was strongly and independently associated with medial cartilage volume loss (-0.31, p=0.0004).

                      Conclusion: These data demonstrate that bone lesions are prevalent in knee OA. The correlation of the edema and cyst size increase in the medial compartment over time with a greater loss of cartilage volume in this area underlines the importance of subchondral bone lesions in OA pathophysiology.

                      • bone lesions
                      • cartilage volume loss
                      • knee OA
                      • qMRI

                      Statistics from Altmetric.com

                      Request permissions

                      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.