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The B cell in systemic lupus erythematosus: a rational target for more effective therapy
  1. D B Driver (catherine.driver{at}
  1. Cedars-Sinai Medical Center, United States
    1. M Ishimori (mariko.ishimori{at}
    1. Cedars-Sinai Medical Center, United States
      1. M H Weisman (weisman{at}
      1. Cedars-Sinai Medical Center, United States


        Current treatment options for systemic lupus erythematosus (SLE) are diverse and poorly defined, and aggressive therapy can be associated with serious toxicity and tolerability issues. There is, therefore, a need for new and improved treatments to be studied thoroughly in well-designed controlled trials. B-cell dysfunction has emerged as a key pathophysiological component of SLE and is a prime target for the development of new agents for a wide range of lupus severity, including advanced disease. Although many current drugs appear to modify B-cell function, the advent of new targeted therapies offers the hope of improved efficacy and a better long-term tolerability profile.

        • B-cells
        • pathogenesis
        • systemic lupus erythematosus

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