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Rheumatoid arthritis bone erosion volumes on CT and MRI –reliability and correlations with erosion scores on CT, MRI and radiography
  1. Uffe Møller Døhn (umd{at}dadlnet.dk)
  1. Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Denmark
    1. Bo j Ejbjerg (ejbjerg{at}dadlnet.dk)
    1. Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Denmark
      1. Maria Hasselquist
      1. Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Denmark
        1. Eva Narvestad
        1. Department of Radiology, Copenhagen University Hospital Rigshospitalet, Denmark
          1. Michel Court-Payen
          1. Department of Radiology, Copenhagen University Hospital Rigshospitalet, Denmark
            1. Marcin Szkudlarek
            1. Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Denmark
              1. Jakob Møller
              1. Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Denmark
                1. Henrik S. Thomsen
                1. Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Denmark
                  1. Mikkel Østergaard
                  1. Departments of Rheumatology, Copenhagen University Hospitals at Hvidovre and Herlev, Denmark

                    Abstract

                    Objectives: To investigate intra-and intermodality agreements of CT and MRI erosion volumes in RA metacarpophalangeal (MCP) joints, and to compare the volumes with erosion scores for CT, MRI and radiography.

                    Methods: Seventeen RA-patients and four healthy controls underwent unilateral CT, MRI and radiography of one hand’s 2nd-5th MCP-joints. Erosion volumes (using OSIRIS software) and scores were determined from radiography (only scores), CT and MRI.

                    Results: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean erosion volume was 26 (median 10; range 0-248) mm3, while 30 (18; 1-163) mm3 on MRI. Total erosion volumes (per patient/control) were 97 (29; 0-485) mm3 on CT and 90 (46; 0-389) mm3 on MRI. For volumes, Spearman’s correlation coefficients were 0.96-0.99 (CT vs. CT), 0.95-0.98 (MRI vs. MRI) and 0.64-0.89 (CT vs. MRI), all p<0.01. MRI erosion volumes correlated with OMERACT-RAMRIS erosion scores 0.91-0.99 (p<0.01) and the Sharp/van der Heijde erosion score (0.49-0.63; p<0.01).

                    Conclusion: Very high intramodality and high intermodality agreements of CT and MRI erosion volumes were demonstrated, encouraging further testing in longitudinal studies. A close correlation with CT and MRI erosion volumes supports the OMERACT-RAMRIS erosion score as being a valid measure of RA joint destruction.

                    • bone erosions
                    • computed tomography
                    • magnetic resonance imaging
                    • rheumatoid arthritis

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