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Ann Rheum Dis doi:10.1136/ard.2007.069831

Vitamin D and autoimmunity: new etiological and therapeutical considerations

  1. Yoav Arnson (yoavar{at}zahav.net.il)
  1. Department of Medicine 'D', Meir Medical Center, Kfar-Saba, Tel-Aviv University, Tel-Aviv, Israel
    1. Howard Amital (hamital{at}netvision.net.il)
    1. Department of Medicine 'D', Meir Medical Center, Kfar-Saba, Tel-Aviv University, Tel-Aviv, Israel
      1. Yehuda Shoenfeld (shoenfel{at}post.tau.ac.il)
      1. Department of Medicine 'B' and Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv Univer, Israel
        • Published Online First 8 June 2007

        Abstract

        Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis. Several observations have demonstrated that vitamin D inhibits proinflammatory processes by suppressing the enhanced activity of immune cells that take part in the autoimmune reaction. Moreover, recent evidence strongly advocates that supplementation of vitamin D may be therapeutically beneficial particularly for Th1 mediated autoimmune disorders. Some reports imply that vitamin D may even be preventive in certain disorders such as multiple sclerosis and diabetes type 1. It seems that vitamin D has crossed the boundaries of calcium metabolism becoming familiar as a significant factor taking part in diverse physiological functions in general and specifically as a biological inhibitor of inflammatory hyperactivity.

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