Vitamin D and autoimmunity: new etiological and therapeutical considerations
- Yoav Arnson ( )
- Howard Amital ( )
- Yehuda Shoenfeld ( )
- Department of Medicine 'B' and Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv Univer, Israel
- Published Online First 8 June 2007
Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis. Several observations have demonstrated that vitamin D inhibits proinflammatory processes by suppressing the enhanced activity of immune cells that take part in the autoimmune reaction. Moreover, recent evidence strongly advocates that supplementation of vitamin D may be therapeutically beneficial particularly for Th1 mediated autoimmune disorders. Some reports imply that vitamin D may even be preventive in certain disorders such as multiple sclerosis and diabetes type 1. It seems that vitamin D has crossed the boundaries of calcium metabolism becoming familiar as a significant factor taking part in diverse physiological functions in general and specifically as a biological inhibitor of inflammatory hyperactivity.