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Cellular targets of Interleukin-18 in rheumatoid arthritis
  1. Sheng-Ming Dai (dsm{at}
  1. Changhai Hospital, Second Military Medical University, China
    1. Zheng-Zheng Shan, Dr
    1. Changhai Hospital, Second Military Medical University, China
      1. Huji Xu
      1. Changzheng Hospital, China
        1. Kusuki Nishioka (k4nishi{at}
        1. Institute of Medical Science, St. Marianna University School of Medicine, Japan


          Recent data are presented illustrating a critical role of IL-18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in synovial fluid are chief cellular targets of IL-18 in RA. Neutrophils, dendritic cells and endothelial cells may also be the cellular mediators of IL-18. The direct effect of IL-18 on fibroblast-like synoviocytes or chondrocytes may not be essential or important. In RA, IL-18, mainly produced by macrophages, activates T cells and macrophages to produce proinflammatory cytokines, chemokines, adhesion molecules and RANKL, which in turn perpetuates chronic inflammation, and induces bone and cartilage destruction.

          • chondrocytes
          • interleukin-18
          • macrophages
          • rheumatoid arthritis
          • synoviocytes

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