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QUEST-RA: Quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries
  1. Tuulikki Sokka (tuulikki.sokka{at}ksshp.fi)
  1. Jyväskylä Central Hospital, Finland
    1. Hannu Kautiainen
    1. Medcare, Finland
      1. Sergui Toloza
      1. Hospital San Juan Bautista, Argentina
        1. Heidi Mäkinen
        1. Jyväskylä Central Hospital, Finland
          1. Suzanne MM Verstappen
          1. University Medical Center Utrecht, Netherlands
            1. Merete Lund Hetland
            1. Copenhagen Univ Hospital, Denmark
              1. Antonio Naranjo
              1. Hospital de Gran Canaria Dr. Negrin, Spain
                1. Eva Baecklund
                1. Uppsala University Hospital, Sweden
                  1. Gertraud Herborn
                  1. Evangelisches Fachkrankenhaus, Germany
                    1. Rolf Rau
                    1. Evangelisches Fachkrankenhaus, Germany
                      1. Massimiliano Cazzato
                      1. Santa Chiara Hosp, Italy
                        1. Laure Gossec
                        1. Hôpital Cochin, France
                          1. Vlado Skakic
                          1. Rheumatology Institut, Serbia and Montenegro
                            1. Feride Gogus
                            1. Gazi Medical School, Turkey
                              1. Stanislaw Sierakowski
                              1. Medical University in Bialystok, Poland
                                1. Barry Bresnihan
                                1. St. Vincent University Hospital, Eire
                                  1. Peter Taylor
                                  1. Charing Cross Hosp, United Kingdom
                                    1. Catherine McClinton
                                    1. Charing Cross Hosp, United Kingdom
                                      1. Theodore Pincus, for the QU
                                      1. Vanderbilt University, United States

                                        Abstract

                                        Objective: To conduct a cross sectional review of non-selected consecutive out-patients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA.

                                        Methods: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease, and treatment related variables were collected and analyzed using descriptive statistics. Variation in disease activity on DAS28 within and between countries was graphically analyzed. A median regression model was applied to analyze differences in disease activity between countres.

                                        Results: Between January 2005 and October 2006, the QUEST-RA project included 4,363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years, and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but 3 countries. Overall, patients had an active disease with a median DAS28 of 4.0 with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28<3.2 was met by the majority of patients in 7 sites in 5 countries; in 8 sites in 5 other countries >50% of patients had high disease activity of DAS>5.1.

                                        Conclusions: This international multi-center cross sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-06 including countries that are infrequently involved in clinical research projects.

                                        • DAS28
                                        • clinical evaluation
                                        • outcomes
                                        • rheumatoid arthritis

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