Article Text

other Versions

PDF
Research in hand osteoarthritis: time for reappraisal and demand for new strategies.
  1. Margreet Kloppenburg (g.kloppenburg{at}lumc.nl)
  1. Leiden University Medical Center, Netherlands
    1. Tanja Stamm
    1. Medical University of Vienna, Austria
      1. Iain Watt
      1. Leiden University Medical Center, Netherlands
        1. Franz Kainberger
        1. Medical University of Vienna, Austria
          1. Tim E Caston
          1. School of Clinical Medical Sciences, Newcastle University, United Kingdom
            1. Fraser N Birrell
            1. School of Clinical Medical Sciences, Newcastle University, United Kingdom
              1. Ingemar F Petersson
              1. Spenshult Hospital for Rheumatic Diseases, Sweden
                1. Tore Saxne
                1. Lund University Hospital, Sweden
                  1. Tore K Kvien
                  1. Diakonhjemmet Hospital, Oslo, Norway
                    1. Barbara Slatkowsky-Christensen
                    1. Diakonhjemmet Hospital, Oslo, Norway
                      1. Maxime Dougados
                      1. Rene Descartes, Cochin Hospital, Paris, France
                        1. Laure Gossec
                        1. René-Descartes University, Cochin Hospital, Paris, France
                          1. Ferdinand C Breedveld
                          1. Leiden University Medical Center, Netherlands
                            1. Josef S Smolen
                            1. Medical University of Vienna, Austria

                              Abstract

                              Background: Osteoarthritis (OA) of the hands is a prevalent musculoskeletal diseases with much impact, but knowledge and research results in the field of hand OA are limited. Therefore the DICHOA (Disease Characteristics in Hand OA) initiative was founded in early 2005 with the aim to address key issues and facilitate research in hand OA.

                              Objective: To review and discuss current knowledge on hand OA with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures.

                              Methods: Recommendations were made based on a literature review.

                              Results: Outcomes of hand OA should be explored, including separately disease activity, damage and functioning from the perspective of patients. All imaging modalities should be cross-validated in hand OA to clinical status, including disease activity, function and performance, biomarkers and long-term outcome. New imaging modalities are available and need scoring systems and validation. The role of biomarkers in hand OA has to be defined.

                              Conclusion: Future research in hand OA is warranted.

                              • biomarkers
                              • hand
                              • imaging
                              • osteoarthritis
                              • outcome measures

                              Statistics from Altmetric.com

                              Request permissions

                              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.