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Anti-TNFα therapy in patients with impaired renal function
  1. Axel J Hueber (axel_hueber{at}web.de)
  1. University of Erlangen, Germany
    1. Andac Tunc (andac_tunc{at}web.de)
    1. University of Erlangen, Germany
      1. Georg Schett (georg.schett{at}med3.imed.uni-erlangen.de)
      1. University of Erlangen, Germany
        1. Bernhard Manger (bernhard.manger{at}med3.imed.uni-erlangen.de)
        1. University of Erlangen, Germany

          Abstract

          Renal insufficiency is a frequent comorbidity in patients with inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Decreased renal function is a limiting factor for the use of non-steroidal and anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). Therefore, therapeutic alternatives would be an improvement of our treatment options for these patients. For tumour necrosis factor α (TNFα) inhibitors no data about their use in patients with impaired renal function are available, because it has been an exclusion criterion in all major clinical trials.

          • TNF antagonists
          • psoriatic arthritis
          • renal insufficiency
          • rheumatoid arthritis

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