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Progression of radiographic damage in patients with ankylosing spondylitis - Defining the central role of syndesmophytes
  1. X Baraliakos (xenob{at}onlinehome.de)
  1. Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Germany
    1. J Listing (listing{at}drfz.de)
    1. German Rheumatism Research Centre, Germany
      1. M Rudwaleit (martin.rudwaleit{at}charite.de)
      1. Charité Universitymedicine Berlin, Campus Benjamin Franklin, Germany
        1. H Haibel (hildrun.haibel{at}charite.de)
        1. Charité Universitymedicine Berlin, Campus Benjamin Franklin, Germany
          1. J Brandt (brandt.rheumatologie{at}arcor.de)
          1. Rheumatologie Praxis Berlin, Germany
            1. J Sieper (joachim.sieper{at}charite.de)
            1. University Clinic Benjamin Franklin, Germany
              1. J Braun (j.braun{at}rheumazentrum-ruhrgebiet.de)
              1. Rheumazentrum Ruhrgebiet, Germany

                Abstract

                Background:Structural changes such as erosions, syndesmophytes and ankylosis are characteristic for ankylosing spondylitis (AS). These can be quantified by the modified Stokes AS spinal score (mSASSS). It is unknown which radiographic feature is most relevant for the assessment of change and the prediction of future damage in AS.

                Objectives:Radiographic progression was analysed in AS by using different assessments to define the most important changes.

                Methods:Spinal radiographs of 116 AS patients were scored by the mSASSS at baseline (BL) and after 2 years (FU). Radiographic progression was assessed by differentiating 1.any change, 2.progression to syndesmophytes/ankylosis (definite change), and 3.changes exceeding the smallest detectable change (SDC) as predefined. A growth angle of 45o was used to differentiate syndesmophytes from spondylophytes.

                Results:Any radiographic progression after 2 years was detected in 42%, novel syndesmophytes in 31%, and, using the SDC (calculated at 2 mSASSS units) as cut- off, progression was seen in 28% of patients. Thus, in 74% of the patients changes were due to syndesmophytes and/or ankylosis. Using the predefined cut-off, only 12% of all syndesmophytes were spondylophytes. Patients with such changes were older. Definite radiographic progression was found in 44% of the patients with syndesmophytes/ankylosis at BL (n=57) vs. 19% (p=0.03) of the patients without such changes (n=59).

                Conclusions:Syndesmophytes and ankylosis are the most relevant structural changes in AS, also in the mSASSS. Development of just one syndesmophyte within 2 years indicates progression of structural changes in AS, this is relevant for clinical practice. Syndesmophytes are the best predictors of radiographic progression.

                • ankylosing spondylitis
                • baseline damage
                • modified SASSS
                • predictive factors
                • radiographic progression

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