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The epidemiology of ankylosing spondylitis and the commencement of anti-TNF therapy in daily rheumatology practice.
  1. Bert Vander Cruyssen (bert.vandercruyssen{at}ugent.be)
  1. UZ Gent, Belgium
    1. Clio Ribbens (clio.ribbens{at}chu.ulg.ac.be)
    1. University Hospital Sart Tilman , Liège, Belgium
      1. Annelies Boonen (aboo{at}sint.azm.nl)
      1. University Hospital Maastricht, Belgium
        1. Herman Mielants (herman.mielants{at}ugent.be)
        1. Gent University Hospital, Belgium
          1. Kurt de Vlam (kurt.devlam{at}uz.kuleuven.ac.be)
          1. University Leuven, Belgium
            1. Jan lenaerts (jan.lenaerts{at}skynet.be)
            1. Virga Jesse Hospital Hasselt, Belgium
              1. Serge Steinfeld (ssteinfe{at}ulb.ac.be)
              1. Erasme University Hospital, Brussels, Belgium
                1. Filip Van den Bosch (filip.vandenbosch{at}ugent.be)
                1. Ghent university, Gent, Belgium
                  1. Lode Dewulf (lode.dewulf{at}spcorp.com)
                  1. Schering Plough, Brussels, Belgium
                    1. Nathan Vastesaeger (nvastesa{at}cntnl.jnj.com)
                    1. Schering Plough, Brussels, Belgium

                      Abstract

                      Objectives: This study aimed to describe the epidemiology of ankylosing spondylitis (AS) in rheumatology practice at the beginning of the anti-TNF era, and to evaluate the initiation of anti-TNF therapy in a clinical setting where prescription is regulated by authority's imposed reimbursement criteria.

                      Methods: Between February 2004 and February 2005, all Belgian rheumatologists in academic and non-academic out-patient settings were invited to register all AS patients who visited their practice. A random sample of these patients was further examined by an in-depth clinical profile. In a follow-up query, we recorded whether patients initiated anti-TNF therapy and compared this to their eligibility at baseline evaluation.

                      Results: Eighty-nine rheumatologists participated and registered 2141 patients; 1023 patients were clinically evaluated, of whom 847 fulfilled the New York modified criteria for definite AS and 176 of probable AS. The profile of AS in rheumatology practice is characterized by longstanding and active disease with a high frequency of extra-articular manifestations and metrological and functional impairment. Median 2 months after the clinical evaluation, anti-TNF therapy was initiated in 263 of 603 (44%) evaluable patients with definite AS and in 22 of 138 (16%) evaluable patients with probable AS (total 38%). More than 85% of the patients who started anti-TNF therapy had an increased Bath Ankylosing Spondylitis Disease Activity Index despite previous NSAID use.

                      Conclusions: Of a representative cohort of 1023 Belgian AS patients seen in daily rheumatology practice, about 40% commenced anti-TNF therapy. Decision factors to start anti-TNF therapy may include disease activity and severity.

                      • Ankylosing spondylitis
                      • Anti-TNF therapy
                      • Epidemiology
                      • Spondyloarthropathy

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