Objective: We aimed to replicate the association of frizzled-related protein (FRZB) non-synonymous polymorphisms with osteoarthritis (OA) susceptibility.
Methods: Three groups of Spanish OA patients were included: with total joint replacement due to primary OA in the hip (THR, n = 310), or the knee (TKR, n = 277), or with hand OA (HOA, n = 242). Controls were more than 55 years old and did not show OA (n = 294). SNPs rs288326 (R200W) and rs7775 (R324G) were genotyped.
Results: There were not significant differences in allele frequencies between controls and each of the three groups of OA patients. However, allele G of the R324G SNP showed a trend to be more frequent in patients with a clinical OA syndrome at multiple joints (p = 0.07), specifically in women of the THR group (8.3 % in THR patients without other affected joints, 13.1 % with one, 15.9 % with two and 24.1 % with more than two additional joints, p for trend = 0.008).
Conclusions: No direct replication of previous OA association findings was obtained but our results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip, in female patients. This phenotype could conciliate previous studies that showed association either with generalized OA or with hip OA in females.
- frizzled-related protein
- genetic susceptibility