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African American and Hispanic ethnicities, renal involvement and obesity predispose to hypertension in Systemic Lupus Erythematosus: Results from LUMINA, a multiethnic cohort. (LUMINA XLV)
  1. Sumapa Chaiamnuay (sumapa.chaiamnuay{at}ccc.uab.edu)
  1. University of Alabama at Birmingham, United States
    1. Ana M. Bertoli (anabertoli{at}yahoo.com)
    1. University of Alabama at Birmingham, United States
      1. Jeffrey M. Roseman (bush{at}uab.edu)
      1. University of Alabama at Birmingham, United States
        1. Gerald McGwin, Jr (gerald.mcgwin{at}ccc.uab.edu)
        1. University of Alabama at Birmingham, United States
          1. Mandar Apte (mandar.apte{at}ccc.uab.edu)
          1. University of Alabama at Birmingham, United States
            1. Luis M Vila (lvila{at}rcm.upr.edu)
            1. University of Puerto Rico Medical Sciences Campus, Puerto Rico
              1. Sergio Duran (sergio.duran{at}ccc.uab.edu)
              1. The University of Alabama at Birmingham, United States
                1. John D. Reveille (john.d.reveille{at}uth.tmc.edu)
                1. University of Texas, United States
                  1. Graciela S Alarcón (graciela.alarcon{at}ccc.uab.edu)
                  1. University of Alabama at Birmingham, United States

                    Abstract

                    Objective:To examine the predictors of the occurrence of hypertension in a large multiethnic US cohort.

                    Patients/methodsThere were 614 SLE patients [(¡Ý4 ACR revised criteria), ¡Ü 5 years disease duration at entry into the cohort (T0)and of Hispanic (Texan or Puerto Rican), African American, or Caucasian ethnicity] at the time these analyses were performed. T0 variables were compared between patients who did and did not developed hypertension (a blood pressure ¡Ý140/90 mmHg on at least two occasions and/or the use of antihypertensive medications) after T0. Significant and clinically relevant variables were then examined by a stepwise logistic regression model.

                    ResultsA total of 379 patients without hypertension at T0 were included [patients who developed hypertension prior to SLE diagnosis (n=126) or before T0 (n=109) were excluded]. Predictors of hypertension were African American and Texan-Hispanic ethnicities, renal involvement and a higher body mass index.

                    ConclusionsTraditional cardiovascular risk factors, disease-related factors and ethnicity play a role in the occurrence of hypertension in SLE patients. Controlling renal involvement and optimizing body weight may prevent the occurrence of hypertension.

                    • ethnicity
                    • hypertension
                    • lupus
                    • obesity

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