Objective:To examine the predictors of the occurrence of hypertension in a large multiethnic US cohort.
Patients/methodsThere were 614 SLE patients [(¡Ý4 ACR revised criteria), ¡Ü 5 years disease duration at entry into the cohort (T0)and of Hispanic (Texan or Puerto Rican), African American, or Caucasian ethnicity] at the time these analyses were performed. T0 variables were compared between patients who did and did not developed hypertension (a blood pressure ¡Ý140/90 mmHg on at least two occasions and/or the use of antihypertensive medications) after T0. Significant and clinically relevant variables were then examined by a stepwise logistic regression model.
ResultsA total of 379 patients without hypertension at T0 were included [patients who developed hypertension prior to SLE diagnosis (n=126) or before T0 (n=109) were excluded]. Predictors of hypertension were African American and Texan-Hispanic ethnicities, renal involvement and a higher body mass index.
ConclusionsTraditional cardiovascular risk factors, disease-related factors and ethnicity play a role in the occurrence of hypertension in SLE patients. Controlling renal involvement and optimizing body weight may prevent the occurrence of hypertension.