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MHC2TA is associated with rheumatoid arthritis in Japanese patients
  1. Noriko Iikuni (iikuni{at}ior.twmu.ac.jp)
  1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
    1. Katsunori Ikari (kikari{at}ior.twmu.ac.jp)
    1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
      1. Shigeki Momohara
      1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
        1. Taisuke Tomatsu
        1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
          1. Masako Hara
          1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
            1. Hisashi Yamanaka
            1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
              1. Hiroshi Okamoto
              1. Institute of Rheumatology, Tokyo Women's Medical University, Japan
                1. Naoyuki Kamatani
                1. Institute of Rheumatology, Tokyo Women's Medical University, Japan

                  Abstract

                  Many diseases have increased expression of both major histocompatibility complex (MHC) class I and II molecules, and particularly the class II genes in the HLA region are known to influence many chronic inflammatory diseases. Recently, a -168A->G polymorphism (rs3087456) in the type III promoter of MHC2TA, which has a pivotal role in MHC class II regulation, was found to be associated with increased susceptibility in rheumatoid arthritis (RA) in a Swedish population. However, most replication studies in other populations did not replicate this finding except Spanish studies. The purpose of this study was to see if the reported association could be observed in a Japanese population.

                  • MHC2TA
                  • association
                  • gene
                  • rheumatoid arthritis

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