Many diseases have increased expression of both major histocompatibility complex (MHC) class I and II molecules, and particularly the class II genes in the HLA region are known to influence many chronic inflammatory diseases. Recently, a -168A->G polymorphism (rs3087456) in the type III promoter of MHC2TA, which has a pivotal role in MHC class II regulation, was found to be associated with increased susceptibility in rheumatoid arthritis (RA) in a Swedish population. However, most replication studies in other populations did not replicate this finding except Spanish studies. The purpose of this study was to see if the reported association could be observed in a Japanese population.
- rheumatoid arthritis