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β2 Adrenoceptor gene single nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden
  1. B-Y Xu1,
  2. L Ärlehag1,
  3. S-B Rantapää-Dahlquist2,
  4. A K Lefvert1
  1. 1Immunological Research Laboratory, Centre for Molecular Medicine and Department of Medicine, Karolinska Institutet, Stockholm, Sweden
  2. 2Department of Rheumatology, University Hospital, Umeå, Sweden
  1. Correspondence to:
    Professor A K Lefvert
    Immunological Research Laboratory, CMM, Karolinska Hospital, S-171 76 Stockholm, Sweden; Ann.Kari.Lefvertcmm.ki.se

Abstract

Background: β2 Adrenoceptor (β2-AR) represents a link between the sympathetic nervous system and the immune system, and may be involved in human rheumatoid arthritis (RA). The gene encoding β2-AR contains three single nucleotide polymorphisms (SNPs) at amino acid positions 16, 27, and 164.

Objective: To examine the common variants at positions 16 and 27 and their association with RA.

Methods: An allele-specific polymerase chain reaction to determine the common variants at positions 16 and 27 was used in 154 patients with RA and 198 ethnically matched healthy subjects from northern Sweden.

Results: Carriage of Arg16 and of Gln27 was associated with RA. Carriage of Gln27 was associated with activity of the disease and in combination with non-carriage of Arg16 with higher levels of rheumatoid factor.

Conclusion: The β2-AR SNPs may thus constitute an additional non-major histocompatibility complex association in RA.

  • β2-AR, β2 adrenoceptor
  • CI, confidence interval
  • OR, odds ratio
  • PCR, polymerase chain reaction
  • RA, rheumatoid arthritis
  • RF, rheumatoid factor
  • SNPs, single nucleotide polymorphisms
  • β2 adrenoceptor
  • single nucleotide polymorphisms
  • rheumatoid arthritis

https://doi.org/10.1136/ard.2004.027532

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