Objectives Due to the inconsistent association between high-sensitivity C-reactive protein (hs-CRP) and osteoarthritis (OA), we evaluated the relationship between hs-CRP and various radiographic findings in older adults with OA.
Methods This cross-sectional study recruited 2,400 participants from the population-based Dong-gu cohort. The scores of radiographic features in OA on X-rays of the knees and hands were computed using a semi-quantitative grading system. The hs-CRP levels were measured using a particle-enhanced immunonephelometry assay. Correlations showing the relationship between hs-CRP and OA were calculated using multiple linear correlation analysis.
Results The hs-CRP levels were significantly higher in older subjects (p <0.001), those with a higher body mass index (BMI) (p <0.001), current smokers (p <0.001), current alcohol drinkers (p =0.012), those who were less physically active (p =0.002), and those with a lower level of education (p =0.036). After adjusting for BMI and other confounders, the total OA scores (knee, p =0.048; hand, p =0.010), erosion scores (knee, p =0.035; hand, p =0.031), and sclerosis (knee, p =0.021; hand, p =0.029) in the knees and hands were all significantly positively correlated with hs-CRP. A significant association was also observed between hs-CRP and the hand malalignment score (p =0.012).
Conclusions In this large cross-sectional study, the hs-CRP level was a significant predictor of radiographic OA. Of the various types of OA radiographic damage, erosion, sclerosis, and malalignment showed significant associations with hs-CRP.
Disclosure of Interest None declared