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SAT0408 Positive correlation between inflammation on sacroiliac joint mri and serum c-terminal telopeptide of type-i collagen in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis
  1. KY Kang1,
  2. YS Hong2,
  3. JH Ju3,
  4. S-H Park3
  1. 1Division of Rheumatology, Internal Medicine, Catholic University of Korea, seoul
  2. 2Catholic University of Korea, Incheon
  3. 3Catholic University of Korea, seoul, Korea, Republic Of

Abstract

Background The MRI-determined inflammatory score was suggested as a more objective measure of disease activity than clinical activity scores in axial spondyloarthritis. It would be useful to identify the disease activity scores and/or laboratory biomarkers that objectively reflect inflammation on MRI.

Objectives To identify the clinical disease activity scores and laboratory markers that best reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA).

Methods This cross-sectional study included all consecutive patients who presented with axial spondyloarthritis in 2013–2015. All underwent SIJ MRI. The bone marrow edema in the inflammatory lesions on MRI was scored using the SPondyloArthritis Research Consortium of Canada (SPARCC) method. Bone-specific alkaline phosphatase (BALP), serum C-terminal telopeptide of type-I collagen (sCTX-I), and inflammatory markers were measured. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS) were assessed. The correlations between the MRI-determined SIJ inflammation scores and disease activity scores and laboratory variables were evaluated.

Results Of the 81 patients with axSpA, 45 had AS and 36 had nr-axSpA. The AS and nr-axSpA groups did not differ in terms of disease activity scores, physical functional index, or MRI-determined SIJ inflammation. Erythrocyte sedimentation rate, C-reactive protein, and ASDAS correlated with MRI inflammatory scores in nr-axSpA but not in AS. sCTX-I correlated with MRI-determined SIJ inflammatory scores in AS only. BASDAI and BALP levels did not associate with MRI inflammatory scores in either group. Multivariate analysis showed that sCTX-I associated independently with MRI inflammatory score in AS (β=17.047, p=0.038).

Conclusions Inflammatory markers and ASDAS correlated with active sacroiliitis on MRI in nr-axSpA only. In AS, only sCTX-I correlated with active inflammation on SIJ MRI. sCTX-I may be useful as a marker of objective inflammation in AS.

Disclosure of Interest None declared

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