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SAT0135 Cardiovascular risk in rheumatoid arthritis patients from southern brazil and its association with serum levels and genotypic variation of mannose binding lectin
  1. B Stadler1,
  2. TAFG Dos Santos1,
  3. T Skare1,
  4. R Nisihara1,2,
  5. R Petisco3,
  6. I Goeldner2,
  7. S Utiyama4,
  8. IJT Messias-Reason2
  1. 1Rheumatology Unit, Hospital Universitário Evangelico de Curitiba
  2. 2Department of Medical Pathology, Federal University of Paraná
  3. 3Evangelic School of Medicine
  4. 4Department of Clinical Analysis, Federal University of Paraná, Curitiba, Brazil

Abstract

Background The binding lectin mannose (MBL) is a serum protein of collectin family that appears to be involved in the inflammatory process and in the genesis of atherosclerotic disease.

Objectives To study the association of serum levels of MBL and its genotypic variation with carotid arteries intimal thickness (IMT) in rheumatoid arthritis (RA) patients from Southern Brazil.

Methods Serum level, MBL genotyping and IMT were studied in 90 RA patients along with their demographic, clinical and laboratory profile. MBL levels were measured in 90 healthy controls.

Results There was significant difference between mean serum levels of MBL in patients with RA and controls (528 ng/mL vs 937.5 ng/mL, p=0.05, respectively). The median IMT in RA patients was 0.59 mm (0.51 to 0.85 mm). There was no correlation between levels of MBL with disease activity measured by DAS-28 (disease activity score-28), erythrocyte sedimentation rate (ESR), autoantibodies presence or IMT (p=NS). A negative correlation was found between MBL levels with CRP levels (p=0.02). The mutation vat codon 54 (variant B) and HYPA haplotype were the most frequent (67.5% and 31.7%, respectively) in the RA sample. Dominant genotypes (A/A) are associated with lower IMT when compared with heterozygotes (A/O; p=0.04) and homozygous recessive (O/O; p=0.05). Also dominant genotypes had lower CRP when compared with heterozygous (p=0.04) or with recessive genotypes (p=0.05).

Conclusions RA patients had lower MBL levels than controls. MBL serum levels are negatively associated with CRP; low producers of MBL had increased thickness of the IMT than high producers.

References

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  2. Ip WK, Lau YL, Chan SY, Mok CC, Chan D, Tong KK, et al. Mannose-binding lectin and rheumatoid arthritis in southern Chinese. Arthritis Rheum. 2000;43(8):1679–87.

  3. J Maury CP, Aittoniemi J, Tiitinen S, Laiho K, Kaarela K, Hurme M, et al. Variant mannose-binding lectin 2 genotype is a risk factor for reactive systemic amyloidosis in rheumatoid arthritis. Jounal Intern Med. 2007;262:466–9.

  4. Graudal NA, Homann C, Madsen HO, Svejgaard A, Jurik AG, Graudal HK, et al. Mannan Binding Lectin in Rheumatoid Arthritis. A Longitudinal Study. J Rheumatol. 1998;25(4):629–35.

  5. Carvalho EG, Utiyama SRR, Kotze LMS, Reason ITM. Lectina ligante de manose (MBL): características biolόgicas e associação com doenças. Res bras alerg imunopatol. 2007;30(5):187–93.

References

Disclosure of Interest None declared

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