Objectives The present study explored the correlation of soluble CD163 with refractory systemic-onset juvenile idiopathic arthritis (refractory So-JIA) as well as the clinical significanceof soluble CD163 in (refractory So-JIA).
Methods A total of 33 young patients diagnosed with So-JIA in the active period and 30 young patients diagnosed with So-JIA in the inactive period at Guangzhou Women and Children's Medical Center (Guangzhou, China) from January 2010 to January 2012 as well as 40 age-matched healthy individuals, who had visited the hospital for medical examination in the same time-period were enrolled in the present study. Flow cytometry was used to determine the lymphocyte count and ELISA was adopted for determining the levels of soluble CD163 in serum
Results The levels of soluble CD163 and their correlation with indexes of disease activity were observed. In patients with So-JIA in the active period, the levels of soluble CD163 and the Tcell count were significantly higher than those in the inactive So-JIA and healthy individuals (P<0.05). Furthermore, the levels of soluble CD163 were positively correlated with C-reactive protein, ferritin, erythrocyte sedimentation rate, white blood cell count and immunoglobulin E as indexes of disease activity (P<0.05).
Conclusions Soluble CD163 is a more valuable index for early recognise refractory active So-JIA, which can provide a basis for active period development and clinical observation.
Disclosure of Interest None declared