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FRI0615 Sarcoidosis and cancer: different patterns of association in a multicenter cohort from southern europe
  1. R Pérez-Alvarez1,
  2. B Kostov2,
  3. A García González3,
  4. R Gόmez De La Torre4,
  5. M Lopez Dupla5,
  6. B De Escalante6,
  7. A Alguacil7,
  8. J Chara8,
  9. J Velilla9,
  10. J Rascόn10,
  11. JS Garcia Morillo11,
  12. C Tolosa12,
  13. E Fonseca13,
  14. M Bonet14,
  15. JL Callejas15,
  16. G de la Red16,
  17. E Calvo17,
  18. A Gόmez Lozano18,
  19. E Peral19,
  20. JF Gόmez Cerezo20,
  21. G Cruz21,
  22. P Perez22,
  23. S Fernández Rodríguez23,
  24. B Pinilla24,
  25. A Gato25,
  26. M Akasbi26,
  27. A Robles27,
  28. I Ojeda28,
  29. MJ Vives29,
  30. C Morcillo30,
  31. M Penadés31,
  32. M De Vicente32,
  33. M Ramos-Casals33,
  34. L Pallarés10,
  35. P Brito-Zerόn30,33,
  36. on behalf of the SARCOGEAS-SEMI Registry
  1. 1Hosp Alvaro Cunqueiro, Vigo
  2. 2IDIBAPS, Barcelona
  3. 3Hosp Ramόn y Cajal, Madrid
  4. 4HUCA, Oviedo
  5. 5Hosp Joan XXIII, Tarragona
  6. 6Hosp Clínico, Zaragoza
  7. 7Hosp Virgen de la Salud, Toledo
  8. 8Hosp Josep Trueta, Girona
  9. 9Hosp Miguel Servet, Zaragoza
  10. 10Hosp Son Espases, Palma de Mallorca
  11. 11Hosp Virgen del Rocio, Sevilla
  12. 12Hosp Parc Taulí, Sabadell
  13. 13Hosp Cabueñes, Gijόn
  14. 14Althaia, Manresa
  15. 15Hosp San Cecilio, Granada
  16. 16Hosp Esperit Sant, Santa Coloma
  17. 17Hosp San Jorge, Huesca
  18. 18Hosp Sta Caterina, Girona
  19. 19Hosp Virgen Macarena, Sevilla
  20. 20Hosp Infanta Sofía, Madrid
  21. 21Hosp de Poniente, Almería
  22. 22Hosp Puerta del Mar, Cádiz
  23. 23Hosp da Barbanza, A Coruña
  24. 24Hosp Gregorio Marañόn, Madrid
  25. 25CH, Albacete
  26. 26Hosp Infanta Leonor
  27. 27Hosp la Paz, Madrid
  28. 28Hosp Valle del Guadiato, Cόrdoba
  29. 29San Joan de Déu, San Boi
  30. 30Hosp CIMA-Sanitas, Barcelona
  31. 31Hosp de Manises, Valencia
  32. 32Hosp Nuestra Señora del Prado, Talavera
  33. 33Hosp Clínic, Barcelona, Spain

Abstract

Objectives To evaluate the temporal association between the diagnosis of neoplasia and sarcoidosis in a large cohort of Spanish patients with sarcoidosis.

Methods In January 2016, the Autoimmune Diseases Study Group (GEAS-SEMI) created a national registry (SARCOGEAS) of patients with sarcoidosis. Sarcoidosis was diagnosed with the criteria proposed by the ATS/ERS/WASOG 1999 statement, and extrathoracic disease by the 2014 WASOG instrument. Diagnosis of neoplasia was recorded before and after the diagnosis of sarcoidosis.

Results The cohort included 1082 patients (82% biopsy-proven, 618 women, mean age 47yrs). Association with neoplasia was detected in 135 (13%) patients who developed 140 neoplasms (110 solid and 30 hematological neoplasia). The neoplasia more frequently reported were breast (n=18), lymphoma (n=16), non-melanoma skin (n=15) and colon (n=15). Association with neoplasia was more frequent in patients born in Spain (97% vs 86%, p<0.001, OR 4.06), older patients (55 vs 46yrs, p<0.001, OR 1.03) and those with bone marrow involvement (14% vs 4%, p<0.001, OR 3.64). Patients in whom cancer preceded the diagnosis of sarcoidosis had a higher frequency of sarcoidosis diagnosed incidentally (20% vs 4%, p=0.011) and a lower frequency of ocular sarcoidosis (3% vs 16%, p=0.016). Patients with associated hematological neoplasia had a higher frequency of ENT (13% vs 1%, p=0.009) and bone marrow (33% vs 9%, p=0.002) involvements in comparison with patients with associated solid neoplasia.

Conclusions Association between sarcoidosis and cancer was found in 13% of patients (80% solid and 20% hematologic malignancies). Elderly patients and those born in Spain were at high risk of having associated cancer. Asymptomatic sarcoidosis was more frequently observed in those patients with a previous history of neoplasia, while the association with hematological neoplasms was linked to a higher frequency of sarcoidosis involving ENT and bone marrow.

Disclosure of Interest None declared

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