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FRI0614 Frequency of organ manifestations in chronic sarcoidosis
  1. R Bergner1,
  2. K de Groot2,
  3. GA Müller3,
  4. P Korsten3
  1. 1Medizinische Klinik A, Klinikum Ludwigshafen, Ludwigshafen
  2. 2Medizinische Klinik III, Sana Klinikum Offenbach, Offenbach
  3. 3Klinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Göttingen, Germany

Abstract

Background Chronic sarcoidosis is a systemic disease of unknown etiology, characterized by the histological finding of granulomas in involved organ systems. The most often affected organ is the lung with approximately 90–95%. Systematic data of organ manifestations other than the lung are scarce and show a wide range from 1–2% up to 50% depending on the series.

Methods We analyzed data of newly diagnosed chronic sarcoidosis in 3 tertiary hospitals. We analyzed data on organ manifestations (OM), type of OM and laboratory findings. The certainty of OM was classified as grade 0 (not investigated), grade 1 (no sign of OM), grade 2 (clinical sign of OM), grade 3 (signs of OM in laboratory findings or imaging) and grade 4 (histological proven OM), respectively.

Results We included 151 patients with biopsy-proven chronic sarcoidosis. Mean age was 50.8±15 years with a male predominance (87 [57.2%] vs. 65 [42.8%] patients).

Except for 3 patients, all demonstrated pulmonary involvement. The predominant type of lung involvement was type I (mediastinal lymph node enlargement) in 54.2% and type II (mediastinal lymph node enlargement and interstitial involvement) in 27.7%.

96.5% of patients were investigated for an affection of the kidneys, 97.3% for hepatic, 92.7% for skin involvement, 68.8% for ocular manifestations, 67.5% for ear, nose, throat (ENT) manifestations and 92% for cardiac manifestations, respectively.

Grade 3 (imaging/laboratory) and grade 4 (histology) findings were seen in the kidneys in 7.6/22.8%, in the liver in 13.3/11.9%, in the heart in 10.6/0.7%, in the eyes in 6.6/

Conclusions OM in chronic sarcoidosis are more frequent than suggested in the current literature, especially renal and hepatic. About 20% of patients with chronic sarcoidosis suffered from moderate to severe CKD due to sarcoidosis, which is a major organ complication contributing to overall morbidity.

We recommend a systematic screening for OM in all patients with chronic sarcoidosis as it is performed in other systemic rheumatic disease.

Disclosure of Interest None declared

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