Background inflammation and, levels of inflammatory markers, CRP and other cytokines are important for enhancing insulin resistance in PsA patients.
Inflammation and, levels of inflammatory markers, CRP and other inflammatory cytokines are important players for enhancement and develpoment of insulin resistance in psoriatic arthritis patients.
Objectives To investigate the relation between insulin resistance and psoriatic arthritis presence and disease activity.
To investigate the relation between insulin resistance and disease activity in patients with psoriatic arthritis.
Methods Patients Inclusion criteria: all patients in this study had psoriatic arthritis with disease duration 5 years or more. All under conventional DMARDs treatment in the form of methotrexate 12.5 mg/wk, hydroxychloroquine 400mg/day. With no treatment with glucocorticoids, 3 months prior to enrollment in the study and no previous treatment with biologics. All patients were Postmenopausal females with 3 or more years since menopause.
Exclusion Criteria: DM, ischemic heart disease, hypertension, or any other chronic diseases, Smoking, on medications Medications that affect blood lipids, or body composition and metabolic functions. Postmenopausal females who were on hormonal replacement therapy.
Grouping: G I: Included 50 postmenopausal females with psoriatic arthritis. G II: Included 25 normal postmenopausal females, as a control group.
Methods: 1. Full medical history and Complete clinical examination 2. Anthropometric measurements: Body mass index (BMI), Waist-hip ratio (WHR). 3. The following laboratory investigations were done: C-reactive protein (CRP), Fibrinogen, Fasting insulin. 4. Measures of insulin resistance: Homeostasis model assessment of insulin resistance (HOMA-IR): (a) HOMA 1-IR: It is calculated according to the following equation: Fasting insulin (μU/ml) x FBS (mg/dL)/405. (2). Insulin resistance was defined as HOMA-IR >3. 8. (3), (4). (b) HOMA 2-IR: it is the updated (or computer) model with nonlinear solutions, which also uses paired fasting glucose and insulin values, were calculated using the computer model (HOMA calculator version 2.2).
Results Comparing means of age, BMI, and WHR of both groups' shows no significant difference, which indicates that both groups was matched and valid for comparison. G I have significantly higher values than the control group in the laboratory parameters Insulin, CRP and Fibrinogen as p>0.05, and the insulin resistance parameters (HOMA1, HOMA2). G I was significantly higher than the control group as p>0.05. Significant positive correlation also found between Index for Psoriatic Arthritis (DAPSA) and insulin, HOMA1, and HOMA2.
Conclusions Psoriatic arthritis is associated with increased risk of insulin resistance. PsA activity is strongly associated with developing insulin resistance in psoriatic arthritis patients.
Disclosure of Interest None declared