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FRI0349 The SNP RS6871626 located in IL12B region may influence on vascular lesions of takayasu arteritis
  1. T Nakajima1,
  2. H Yoshifuji1,
  3. C Terao2,
  4. K Murakami1,
  5. R Nakashima1,
  6. Y Imura1,
  7. K Ohmura1,
  8. T Mimori1
  1. 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University
  2. 2Center for Genomic Medicine, Kyoto University, Kyoto, Japan

Abstract

Background Takayasu arteritis (TAK) is a type of large vessel vasculitis, which affects aorta and its main branches. We previously found a single nucleotide polymorphism (SNP), rs6871626 located in IL12B region, as a susceptible gene to TAK and reported that the risk allele at the SNP is associated with the risk of aortic regurgitation (AR)1). However, there have been no studies on the association of the SNP with the organ involvements other than AR in TAK patients.

Objectives To investigate the association of the SNP with arterial and organ involvements except for AR.

Methods We examined the medical records of 85 patients with TAK, stratified them into three groups according to the allele at the SNP, AA (n=26), AC (n=43) and CC (n=16) (A is a risk allele), and investigated the association of the SNP and organ involvements.

Results There were no differences in the complication rates of carotid arterial lesions among the groups (AA 78.9%, AC 63.9% and CC 80.0%). The proportion of patients with lesions in descending aorta (Numano classification2) IIb∼V) was 75.0% in AA, 44.2% in AC 44.2% and 25.0% in CC and the proportion in AA was significantly higher than in CC (p=0.0096). Moreover, estimated glomerular filtration rate (eGFR) was significantly lower in AA than in CC (61.3±26.9ml/min/1.73m2 vs. 81.5±28.8 ml/min/1.73m2, p=0.042).

Table 1.

Organ involvements in patients

Conclusions The SNP rs6871626 located in IL12B may influence on the occurrence of descending aortic lesions in TAK patients and this may lead to renal dysfunction.

References

  1. Terao C et al. Am J Hum Genet. 2013; 93(2): 289–97.

  2. Hata A et al. Int J Cardiol. 1996; 54 Suppl: S155–163.

References

Disclosure of Interest None declared

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