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FRI0334 What is the absolute risk of developing diabetes mellitus in patients with glucocorticoid-treated polymyalgia rheumatica and giant cell arteritis? a systematic review and meta-analysis
  1. L Lai1,
  2. E Harris1 2,
  3. RM West3,
  4. SL Mackie1 4
  1. 1Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds
  2. 2School of Human and Health Sciences, University of Huddersfield
  3. 3Leeds Institute of Health Sciences, University of Leeds
  4. 4NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom

Abstract

Background Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are treated with glucocorticoids (GCs) but long-term GC use is associated with diabetes mellitus (DM). The absolute incidence of this serious complication in this patient group remains unclear.

Objectives To quantify the absolute risk of GC-induced DM in PMR and GCA in published literature.

Methods We identified literature from inception to February 2016 reporting diabetes following exposure to oral GC in patients with PMR and/or GCA without pre-existing diabetes. A random-effects meta-analysis was performed to summarise the literature. Risk of bias was assessed using the Cochrane Collaboration tool.

Results 21 eligible publications were identified. In studies of patients with GCA, mean cumulative GC dose was almost two times higher than in studies of PMR (8.9g vs 5.0g), with slightly longer treatment duration but much longer duration of follow-up (8.8years vs 4.4years). The incidence proportion (cumulative incidence) of patients who developed new-onset DM was 6% (95% CI: 3–9%) for PMR and 12% (95% CI: 8–17%) for GCA. Heterogeneity between studies was high (I2=78.2%), as there were differences in study designs, patient population, geographical locations and treatment strategies. Based on UK data on incidence rate of DM in the general population1, the expected background incidence rate of DM over 4.4 years in PMR patients and 8.8 years in GCA patients (the duration of follow-up) would be 4.8% and 9.7%, respectively. Very little information on predictors of DM in PMR or GCA patients was found. The overall risk of bias was high for many of the observational studies, especially relating to definition and recording of outcome and prognostic variables.

Conclusions Physicians should screen patients treated for PMR/GCA for DM but it remains unclear what is the time-period of greatest risk and the influence of risk factors. Our meta-analysis produced plausible estimates of DM incidence in patients with PMR and GCA but there is insufficient published data to allow precise quantification of the DM risk or, crucially, which patients are at greatest risk.

References

  1. Sharma M et al. BMJ Open, 2016. 6(1): p.e010210.

References

Disclosure of Interest None declared

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