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FRI0333 Ocular involvement in behÇet's disease about 221 cases
  1. K Echchilali,
  2. W Bouissar,
  3. M Moudatir,
  4. F-Z Alaoui,
  5. H Elkabli
  1. Internal Medicine Department, University Hospital Centre Ibn Rochd, Casablanca, Morocco

Abstract

Background Behçet's disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. It's chracterised by recurrent oral aphtosis and genital ulcer. Ocular involvement has been recognized since the time of Hypocrates. Estamates of the prevalence vary in different countries and may represent differences in the disease, in acces to health care and in availabale treatments.

Objectives The aim of this study is to describe the epidemiological and clinical characteristics in moroccan patients with ocular BD.

Methods retrospective study in internal medicine department over 13 years and including 221 patients with ocular BD. The diagnosis was performed by the International Study Group for Behçet's Disease and/or the International Criteria for Behçet's Disease.

Results 221 (prevalence: 43%) had ocular involvement.154 men and 63 women (sex ratio: 2.5). The mean age at the onset of ocular involvement was 30.5 years. This achievement was inaugural in 18.55% of cases. The average time of diagnosis in other cases was 3.41 years.There was a high prevalence of Uveitis (total: 34%, anterior: 32%, posterior: 31.2). Retinal Vasculitis was noted in 37 eyes and retinal detachment in 17 eyes. Neurological events were associated in 13.57% of cases, joint and vascular events in respectively 18 and 17 cases. The topical corticosteroid therapy was prescribed in 27, 14% of cases, oral in 47, 51% and bolus in 29, 41%. 47, 51% of casers received Cyclophosphamide and 19% received Azathioprine. Cyclosporine was administered in 3 cases, interferon and Infkiximab in 2 cases each. The evolution was good in 111 cases (50.22%), treatment failure was noted in 24% of cases and recidivism in 16.74% of cases.63 patients have evolved into blindness which was bilateral in 51.1% of cases.

Conclusions Only early diagnosis and appropriate management can improve the prognosis of ocular involvement in BD.

Disclosure of Interest None declared

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