The pathophysiology of pain in fibromyalgia is complex. In recent years, an involvement of the thinly myelinated nerve fibers of the A-delta type and the unmyelinated C-fibers has been reported in fibromyalgia patients. Independent research groups have published consistent findings of objective injury to these “small nerve fibers”. These included disturbances in function, electrical properties, and morphological integrity of these nerve fibers. While the reasons for this small fiber pathology and its contribution to FMS pain are still unclear, a new research field has emerged that will focus on uncovering the underlying pathophysiology. In this talk, I will summarize current findings and discuss their significance for the understanding of the fibromyalgia syndrome.
Disclosure of Interest C. Sommer Grant/research support from: Kedrion, Speakers bureau: Baxalta, CSL Behring, Genzyme, Grifols, Pfizer