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FRI0098 Elevated multi-biomarker disease activity (MBDA) predicts relapses in ra patients in sustained remission tapering tumour necrosis factor inhibitor therapy- results from the randomized controlled retro study
  1. J Rech1,1,
  2. M Hagen1,
  3. M Englbrecht1,
  4. J Haschka2,
  5. M Reiser1,
  6. A Kleyer1,
  7. A Hueber1,
  8. B Manger1,
  9. C Figuereido3,
  10. J Fogagnolo Cobra3,
  11. H-P Tony4,
  12. S Finzel5,
  13. S Kleinert6,
  14. J Wendler6,
  15. F Schuch6,
  16. M Ronneberger6,
  17. M Feuchtenberger7,
  18. M Fleck8,
  19. K Manger9,
  20. W Ochs10,
  21. M Schmitt-Haendle10,
  22. H-M Lorenz11,
  23. H Nuesslein12,
  24. R Alten13,
  25. J Henes14,
  26. K Krueger15,
  27. G Schett1
  1. 1University of Erlangen-Nuremberg, Erlangen, Germany
  2. 2St.Vincent Hospital, Vinforce Study Group, Medical University of Vienna, Vienna, Austria
  3. 3Institutio de Rheumatologia, Sao Paolo, Brazil
  4. 4University of Wuerzburg, Internal Medicine 2, Wuerzburg
  5. 5University Medical Center Freiburg, Rheumatology and Clinical Immunology, Freiburg
  6. 6Rheumatology Clinical Practice Erlangen, Erlangen
  7. 7Rheumatology Practice and Department of Internal medicine 2, Clinic Burghausen, Burghausen
  8. 8Asklepios Medical Center, Department of Rheumatology and clinical Immunology, Bad Abbach
  9. 9Rheumatology Practice Bamberg, Bamberg
  10. 10Rheumatology Practice Bayreuth, Bayreuth
  11. 11University of Heidelberg, Medicine 5, Heidelberg
  12. 12Rheumatology Practice Nuremberg, Nuremberg
  13. 13Schlosspark Klinik, Internal Medicine/Rheumatology, Berlin
  14. 14University of Tuebingen, Centre for Interdisciplinary Clinical Immunolog, Tuebingen
  15. 15Praxiszentrum St.Bonifatius, Munich, Germany

Abstract

Background Tumor necrosis factor inhibitors (TNFi) are the most frequently used bDMARDs in RA patients. TNFi induces remission in a substantial numbers of patients. Once remission, particularly sustained remission is achieved the question arises whether TNFi can be successfully tapered. To date biomarkers, which can help to predict if TNFi can be tapered or stopped, remain to be developed.

Objectives To test whether residual subclinical inflammation assessed by multi-biomarker disease activity (MBDA) predicts the risk of disease relapse after tapering or stopping TNFi treatment in RA patients in sustained remission.

Methods Sub-analysis of TNFi treated patients of the RETRO study, a randomized-controlled study in RA patients in sustained (>6 month) DAS28 remission comparing 3 different DMARD treatment strategies (continuation of full dose, 50% dose tapering, stopping after 50% dose tapering). Patients were followed over one year for the occurrence of relapses as defined by leaving DAS28-ESR remission (>2.6 units) (1). Vectra-DA tests were done in the baseline samples of all patients included into the RETRO study. MBDA score was calculated according to previously defined algorithms with low MDBA score defined as <30 units and moderate to high scores as ≥30 units (2).

Results Of the 151 patients included in the RETRO study, 42 received TNFi treatment (mean age: 56 ys, 25 (60%) females, 78% concomitant csDMARDs; 69% ACPA/RF positive. Baseline demographic and disease specific characteristics of these patients were comparable to the non-TNFi treated patients of the RETRO study. 26/42 patients (62%) had low MBDA scores at baseline, while 16/42 (38%) had moderate/high scores. Relapse rates were significantly (chi square p=0.016) lower in RA patients with low MBDA scores (N=8 of 26; 31%) than in those with moderate/high scores (N=11 of 16; 69%) (Figure; left graph). When separately analyzing only patients tapering TNFi (N=29), relapse rates were moderate in RA patients with low MBDA scores (N=6 of 16; 37%) but high in those with moderate/high scores (N=10 of 13; 77%) (chi square p=0.015) (Figure; right graph).

Conclusions These data show that the majority of RA patients in sustained clinical remission with low MBDA scores can successfully taper TNFi. In contrast tapering cannot be recommended in patients with moderate to high MBDA scores, as relapse rates are high in these patients.

References

  1. Haschka J et al. Ann Rheum Dis 2016,75;45–51.

  2. Curtis JR et al. Arthritis Care Res 2012;64:1794–803.

References

Disclosure of Interest None declared

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