Background A significant part of patients with inflammatory arthritis are at their reproductive ages. Biological drugs are one of the important treatment options for inflammatory artritis which can cause fetal morbidity and mortality. Management of arthritis during pre-conceptional period is one of the challenges in rheumatology.
Objectives This study aims to assess whether patients under biological treatment share their conception intents with their physicians.
Methods 1580 patients admitted to our outpatient clinic between July 2015 and July 2016 who were received biological treatment. A questionnaire was performed to 373 patients who are at their reproductive ages. Patients were asked whether they or their wifes had got pregnant after the start of biological agent. If they had got, they were asked;
1. Was the pregnancy intented?
2. Did your physician know if you were going to get pregnant while taking a biological agent?
Results There were total of 79 patients who or whose wifes had got pregnant after the start of biological agent. 34 (%43) out of 79 were female and 45 (%57) out of were male. Mean age of patients were 35.1 (5.3). Median disease duration was 10 (IQR=9) years. 24 (30.4%) pregnancies out of 79 were not planned [15 female (44.1%), 9 male (20%), p=0.021]. In addition, 43 (54.4%) out of 79 patients did not share their pregnancy plans with their physicians [15 (44,1%) female and 28 (62,2%) male (p=0.110)]. 28 (35.4%) of all patients stated that their disease was active during pre-conceptional period [20 (58,8%) female patients, 8 (17,8%) male patients, (p<0,001)].
Conclusions In our study group, almost one third of the patients had unplanned pregnancies particularly with in female patients. One third of the patients were in active state before conception according to patients' report. Almost half of the patients did not share their plan of pregnancy with their physicians. We suggest that in routine practise, physicians should ask plan of pregnancy in every clinical visit.
Disclosure of Interest None declared