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THU0506 Association of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet indices and serum amyloid a levels in children with familial mediterranean fever
  1. F Dörtbaş1,
  2. E Comak2,
  3. E Isıyel3
  1. 1Rheumatology, Emsey Hospital, Istanbul
  2. 2Pediatric Nephrology and Rheumatology, Akdeniz University, Antalya
  3. 3Pediatric Nephrology and Rheumatology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey

Abstract

Background Familial mediterranean fever (FMF) is an autosomal recessive, inherited, autoinflammatory disease characterized by recurrent, self-limited bouts of fever and inflammation. Persistent subclinical inflammation was related to increased risk of developing the serious complications, such as life- threatening amyloid a (AA) amyloidosis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet indices [mean platelet volume (MPV) and platelet distribution width (PDW)] are simple, inexpensive, and useful markers to determine inflammation. Although, there have been a lots of data regarding inflammatory markers in FMF, little information was available the relationship between NLR, PLR, MPV and serum amyloid A levels.

Objectives The aim of this study was to investigate association of NLR, PLR, platelet indices and serum amyloid A levels in children with FMF

Methods The medical records of children with FMF were reviewed retrospectively. Information including demographic features, clinical and laboratory findings, SAA and C-reactive protein (CRP) levels, type of MEFV mutation were collected from the hospital's computerized database following approval by the local ethics commitee. The NLR and PLR were calculated from a complete blood count. Children (<7 years old) was excluded from study due to age related features of neutrophil-to-lymphocyte ratio.

Results Our study group included 127 children (60 males, 67 females) with FMF, diagnosed according to the Turkish pediatric FMF criteria. Their mean age was 11.35±3.69 years, their mean age at time of disease onset was 8.73±3.93 years, and their mean follow up period was 28.32±2.90 months. Thirty two children (25.2%) were homozygous, 56 children (44.0%) were compound heterozygous and 39 children (30.7%) were heterozygous for MEFV gene. In study population, the mean SAA levels, C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) were 9.21±13.88 mg/L, 1.38±2.31 mg/dl and 16.64±12.59 mm/hour, respectively. Significant positive correlations were found between SAA, ESR, CRP and NLR (r=0.2, p=0.02; r=0.28, p=0.001; r=0.32, p=0.001, respectively). Hovewer, we did not find any significant correlation between SAA, ESR, CRP and platelet indices (MPV, PDW) and PLR (all p>0.05).

Conclusions Our finding suggest that simply calculating NLR from complete blood count may be used as an additional indicator of inflammation in children with FMF. But, platelet indices and PLR cannot be used as a laboratory markers predicting inflammation in these children.

Disclosure of Interest None declared

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