Article Text

PDF
SP0161 The role of adipose tissue in osteoarthritis
  1. A Ioan-Facsinay
  1. Leiden University Medical Center, Leiden, Netherlands

Abstract

The association between obesity and osteoarthritis (OA) is nowadays well-accepted. This association is present both in weight-bearing and non-weight-bearing joints, indicating that next to local effects, systemic effects associated with obesity could play a role in disease. The relative contribution of local and systemic effects could be different in each joint. In this presentation, I will summarize the current knowledge about the contribution of local and systemic adipose tissues to osteoarthritis in different joints, with emphasis on knee OA. Moreover, obesity-associated changes and their role in OA will be highlighted.

The key messages I would like to convey are:

  • Mechanical stress is a major contributor to knee OA

  • The infrapatellar fat pad (IFP), an intra-articular adipose tissue in the knee, is dostinct from other adipose tissues and could play a role in knee OA

  • Only few obesity-related features have been described in IFP in OA

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.