Article Text

PDF
SP0157 Metabolic phenotype: the two faces of obesity in osteoarthritis
  1. F Berenbaum1,2,3
  1. 1Department of Rheumatology, Sorbonne University
  2. 2INSERM
  3. 3AP-HP Hospital Saint-Antoine, Paris, France

Abstract

Osteoarthritis (OA) has long been considered as the consequence of tear and wear due to mechanical triggers. In that paradigm, the increased risk of OA in obese patients can be explained by overload on weight-bearing joints. The discovery of an increased risk of hand OA in obese patients has changed the paradigm by opening up an additional hypothesis (not ruling out the mechanical hypothesis) based on systemic factors secreted by the adipose tissue (even the central one or/and the intraarticular one), which could have a deleterious effect on joints. More recently, cohorts data have suggested that obese patients with a metabolic syndrome (MetS) (an association of cardiometabolic factors that increase the risk of cardiovascular events i.e. diabetes, hypertension, dyslipidemia) have an increased risk of OA compared to obese patients without MetS. The most recent researches in that field highlight the role of metabolic-triggered inflammation (called meta-inflammation) on the initiation/progression of OA and the role of each of the components of the MetS independently (hyperglycemia, insulinoresistance, oxLDL, endothelial dysfunction, etc.). A better understanding of this newly defined OA phenotype, namely the MetS-associated OA, should lead to the discovery of new drugs specifically targeting this phenotype or/and to assess the efficacy of drugs in OA already on the market for diabetes, hypertension or dyslipidemia.

Disclosure of Interest F. Berenbaum Grant/research support from: Servier, TRB Chemedica, Consultant for: Pfizer, AbbVie, GSK, Flexion Therapeutics, Nordic Bioscience, MerckSerono, Jansen, Expanscience

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.