Multiple studies have demonstrated that rheumatoid arthritis (RA) related biomarkers can identify individuals without inflammatory arthritis who are at high-risk for the future development of clinically apparent synovitis and classified RA. These findings have led to the development of several prevention trials in RA that have either been completed, or are underway. With these exciting developments as background, this lecture will discuss multiple aspects of RA prevention including the role of biomarkers and other factors in developing robust prediction models for future RA, and methods to identify individuals before they develop RA. In addition, this lecture will discuss specific preventive approaches to RA such as clinical trial design and choice of preventive interventions that are based on our growing understanding of the mechanisms of RA development.
Disclosure of Interest None declared