Article Text

PDF
THU0327 Association between the TC/HDL ratio and disease activity in patients with takayasu arteritis
  1. L Pan1,
  2. J Du2,
  3. H Liao1
  1. 1Rheumatology and Immunology
  2. 2Beijing An Zhen Hospital, Capital Medical University., Beijing, China

Abstract

Background Accelerated atherosclerosis has become the main cause of morbidity in patients with autoimmune diseases such as RA and SLE [1]. The Cholesterol/High-density Lipoprotein Cholesterol (TC/HDL-C) ratio is a high discriminatory power index for coronary heart disease. A high TC/HDL-C ratio has been intensively used as a predictor of CVDs [2]. EULAR Task Force recommended that the TC/HDL-C ratio should be regarded as an important prognostic indicator for future cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) [3]. However, the relationship between the TC/HDL-C ratio and disease activity of Takayasu arteritis (TAK) is unclear.

Objectives To investigate changes in the TC/HDL-C ratio and to evaluate the relationship between the TC/HDL-C ratio and disease activity of TAK.

Methods A retrospective study of 103 patients with TAK and 73 healthy controls was performed. We compared the triglyceride (TG), TC, low-density lipoprotein cholesterol (LDL-C), HDL-C and TC/HDL-C ratio between patients and healthy controls, and we analyzed correlations between the lipid parameters and indexes of TAK activity. A ROC curve was used to determine the predictive value of TC/HDL-C ratio in patients group.

Results The TG level was higher in patients with TAK than in the controls (p=0.000). The TC, LDL-C, and HDL-C levels were significantly lower in patients with TAK than in the controls (p=0.000, p=0.000, and p=0.000, respectively). The HDL-C level was significantly lower in the active TAK group than in the inactive TAK group (p=0.005). The TC/HDL-C ratio was significantly increased in patients with disease activity (p=0.001), and it exhibited a positive relationship with the high-sensitivity C-reactive protein level (r=0.234, p=0.003) and Kerr score (r=0.219, p=0.031). In addition, the TC/HDL-C ratio of 3.698 was determined as a predictive cut-off value of TAK (sensitivity 61.0%, specificity 78.6%, area under the curve=0.743) (Figure 1).

Conclusions For the first time, we showed that serum levels of TC, LDL-C, and HDL-C were significantly lower in patients with TAK, and the TC/HDL-C ratio has a positive relationship with the disease activity of TAK, suggesting that the TC/HDL-C ratio may be a potential indicator for monitoring the disease activity of patients with TAK.

References

  1. Symmons DP, Gabriel SE: Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE. Nat Rev Rheumatol 2011, 7(7):399–408.

  2. Zhou Q, Wu J, Tang J, Wang JJ, Lu CH, Wang PX: Beneficial Effect of Higher Dietary Fiber Intake on Plasma HDL-C and TC/HDL-C Ratio among Chinese Rural-to-Urban Migrant Workers. Int J Environ Res Public Health 2015, 12(5):4726–4738.

  3. Peters MJ, Symmons DP, McCarey D, Dijkmans BA, Nicola P, Kvien TK, McInnes IB, Haentzschel H, Gonzalez-Gay MA, Provan S et al: EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis 2010, 69(2):325–331.

References

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.