Background Minor salivary gland biopsy from the lip region is commonly used for primary Sjögren's syndrome (SS) diagnosis. It is accepted that changes of histopathology is the most important component of diagnostic criteria. In this study, we analyzed the relationship between histopathological changes and laboratory findings/clinical features in SS patients and control group.
Objectives The aim of this study was to determine the histopathological changes in minor salivary tissue for SS diagnosis
Methods A total of 69 minor salivary gland biopsies (29 Sjögren's syndrome and 40 controls) were included in the study. Biopsies were evaluated by a blind pathologist unaware of the diagnosis. Histopathological findings were noted as ductal dilatation, fat tissue percentage (<10% or >10%), acinar atrophy, ductal/ acinar ratio and lobules/foci ratio. It was evaluated whether there was a relationship between histological changes and age, gender, ANA, anti-SSA, anti-SSB, RF and Chisholm scores.
Results The lobules/foci ratio of patients with Sjögren's syndrome was significantly higher than the control group (p<0.001). The cutoff value of the lobules/foci ratio for SS diagnosis was 0.8. Furthermore, there was a significant correlations between the lobules/foci ratio greater than 0.8 and antibodies (ANA, RF, anti-Ro) positivity and Chisholm score (p<0.01). Other histopathological findings such as ductal dilatation, fat tissue percentage, acinar atrophy, and ductal/atherine ratio do not distinguish SS from non-SS.
Conclusions The results of this study revealed that only the lobules/foci ratio from histopathological changes has a strong relation with SS diagnosis. It can be important for pathologists to distinguish SS.
Disclosure of Interest None declared
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