The psoriatic disease concept includes the skin disease psoriasis and joint disease psoriatic arthritis. Increasingly, prevalent comorbidities such as obesity and cardiovascular disease are considered to be an integral part of the psoriatic disease concept in many patients.
Within this disease concept, accumulating evidence indicates molecular and cellular cross talk between affected organs and tissues. Skin inflammation affects the bone; nail disease is associated with specific types of arthritis; inflammation links to cardiovascular disease; skin or joint disease may contribute to depression.
Novel therapeutic strategies are reaching psoriatic disease patients as never before. Their global impact could be envisioned from a holistic perspective, optimizing the strategy chosen as determined by the active molecular and cellular network that triggers and sustains disease.
Thus, linking the joints with the skin and other organs involved is proposed as an entry point towards personalized medicine in a complex disease.
Disclosure of Interest R. Lories Grant/research support from: Celgene, Boehringer-Ingelheim, UCB, Consultant for: Janssen, Celgene, Novartis, Pfizer, UCB, Abbvie, Speakers bureau: Janssen, Celgene, Novartis, Pfizer, Merck, UCB, Abbvie
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