Background Osteoarthritis is one of the most painful conditions and the most frequent cause of functional limitation and disability. There are variety of methods used in osteoarthritis (OA) treatment, including, physical therapy, exercise, intraarticular injections, surgery, etc. Platelet-rich Plasma (PRP) is a relatively new autologous biologic treatment that is used for stimulating cartilage healing process and improving the symptoms. Although the effects of PRP injection on pain and function investigated before, as to our knowledge there are no studies related to performance.
Objectives Aim of this study was to investigate effectiveness of PRP on improving function and performance in patients with knee osteoarthritis.
Methods This study included 28 patients (16 F, 12 M) who were affected by grade 1–3 bilateral knee OA according to Kellgren-Lawrence Scale. Patients received three injections of PRP that were performed at monthly intervals by the same doctor. All patients were evaluated before and six months after the first injection. Primary outcome measures were: Stair Climbing Test (SCT), 50-Foot Walk Test (50 FWT), 30-sec Chair Stand Test (30 CST) and Timed Up and Go Test (TUG), IOWA Score. Additionally, Hospital for Special Surgery Score (HSS) was also recorded as a secondary outcome measure. Wilcoxon signed-rank test is used for interpreting the differences between before and after the injections.
Results All patients completed the study with no adverse effects. The mean age of the patients were 59±7.66 years. Improvements were determined for all outcome measures after 6 months regard to baseline results (p<0.01) (Table 1).
Conclusions Our preliminary findings show that PRP is safe and effective autologous biologic agent that might improve function and performance in patients with mild to moderate knee OA and; could be considered as a treatment option in patients with knee OA.
Disclosure of Interest None declared
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