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AB1212-HPR Dynamics of articular syndrome in rheumatoid arthritis against correction of progesterone insufficiency
  1. M Salokhiddinov,
  2. A Ahmedov
  1. Rheumatology and Osteopathy, Tashkent Medical Academy, Tashkent, Uzbekistan


Background According to the literature, sex hormones manifest themselves as immune modulators that inhibit the ones and stimulate other immune functions. Studies have shown that patients with RA, decrease of estradiol and particularly progesterone in the blood serum is found in the women of reproductive age. According to the literature, progesterone has a close relationship with T-cell immunity. A value of T-cell deficiency plays an important role in the cause of the autoimmune process

Objectives To study of progesterone correction in RA patients.The aim of this study was to evaluate the effectiveness of progesterone deficiency correction in patients with rheumatoid arthritis based on the analysis of articular syndrome

Methods The study involved 40 patients with a documented diagnosis of RA, women of reproductive age. The study group consisted of 30 patients who had correction of progesterone deficiency background in the pathogenetic therapy. The control group consisted of 10 female patients who are on the pathogenetic therapy. We used the following criteria: disease activity and severity of the articular syndrome with determining of the number of tender and swollen joints, indices of DAS and HAQ. Statistical analysis of the results of research used the method of parametrics of Student criterion

Results Among the patients studied disease duration ranged from 3 months to 19 years (mean age 10±7,2 years), 20 patients (50%), from 5 to 10 years – 15 (37.5%), and more than 10 years – 5 patients (12.5%). X-ray picture of joint damage in the majority of patients corresponded to stage 2–3 – 87.5% (35 patients). Less common muscular disorders (7.5%), mainly in patients taking long-term GC, myalgia and muscle malnutrition were detected in 7.5% and 25% of patients, respectively. In addition to the articular syndrome, the most frequent complaints of general weakness (75%), irritability, sleep disorders and attention (50%), anxiety and anxiety (75%), low-grade temperature (10%)

Conclusions Progesterone deficiency correction in RA patients against pathogenic therapy has improved performance of articular syndrome and improves quality of life, such as vitality, general health and social function as well as it contributes to the positive dynamics of mental health


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Disclosure of Interest None declared

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