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AB1203-HPR Comparison of quality of life of patients with rheumatoid arthritis, psoriatic arthritis and ankilosing spondilitis with treatment or prescription of biologic drugs: results from the cara study
  1. L Sinigaglia1,
  2. L Scalone2,3,
  3. P Sarzi-Puttini4,
  4. CM Montecucco5,
  5. R Giacomelli6,
  6. G Lapadula7,
  7. I Olivieri8,
  8. A Giardino9,
  9. G Didoni9,
  10. P Cortesi2,3,
  11. LG Mantovani2,3,
  12. M Mecchia9,
  13. on behalf of CARA study working group
  1. 1Rheumatology Unit, G. Pini Hospital
  2. 2CHARTA Foundation, Milano
  3. 3University of Milano Bicocca, Monza
  4. 4Rheumatology Unit, L. Sacco University Hospital, Milano
  5. 5University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia
  6. 6Rheumatology Unit School of Medicine, University of L'Aquila, L'Aquila
  7. 7Rheumatology Unit, University of Bari, Bari
  8. 8San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, and the Basilicata Ricerca Biomedica (BRB) Foundation, Italy, Potenza and Matera
  9. 9MSD Italia, Roma, Italy


Background Chronic rheumatic conditions such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) are associated with severe morbidity and significant impairment of patients' health related quality of life (HRQoL). Several treatments are available but not all the patients respond positively to them. Biologic therapies such as anti-TNFα agents are shown to benefit who fail or have partial responses to standard DMARD therapy.

Objectives Within a multicenter stated preferences study (CARA Study), we assessed HRQoL in patients with RA, AS and PsA, and estimated relationship of HRQOL with the different diagnoses, clinical characteristics and biological treatment experience.

Methods Patients with RA, AS, or PsA, who at the time of enrollment were following a treatment (experienced) or received a first prescription (naïve) of treatment with biological drugs were enrolled. Together with preferences data, clinical and HRQOL information was reported. HRQoL was assessed with the recently developed and successfully validated version of the EQ-5D-5L, which allows to obtain a description of health (in 5 domains and 5 levels of severity each), a measure (EQ-VAS) and a valuation (utility) of health. Multiple linear regression analyses were conducted to assess the association between EQ-5D VAS score and the utility with age, sex, diagnosis, treatment experience, years from symptoms onset and years from diagnosis.

Results 513 patients were enrolled (mean±SD =50.0±13.6, 42.5% female). As regards the diagnosis, 33.9% had RA, 34.9% PsA and 31.2% AS. The mean±SD time from the symptoms onset was 10.8±9.4 and from the diagnosis was 8.0±8.2 years. Almost half of the patients (47.4%) were naïve to the biological treatment. Patients reporting severe or extreme problems were: 7.1% in mobility, 3.6% in self-care, 10.3% in usual activities, 18.6% in pain/discomfort, 5.5% in anxiety/depression. The mean±SD of the VAS was 60.4±20.5 and of the utility was 0.773±0.116. From the regression model the VAS and utility are significantly (p<0.05) associated with age, sex and treatment experience (table 1). In particular, the patients being naïve to the treatment with biological drugs had on average significant worse levels of HRQoL than experienced patients, adjusting for the other variables included in the model.

Table 1.

Results of the regression analyses

Conclusions Patients naïve to biological treatment have significat lower levels of HRQoL, suggesting that their current situation is not satisfactory and need to start with a more effective treatment.

Disclosure of Interest L. Sinigaglia: None declared, L. Scalone: None declared, P. Sarzi-Puttini: None declared, C. Montecucco: None declared, R. Giacomelli Grant/research support from: MSD, G. Lapadula: None declared, I. Olivieri: None declared, A. Giardino Employee of: MSD Italia, G. Didoni Employee of: MSD Italia, P. Cortesi Grant/research support from: Gilead, L. Mantovani: None declared, M. Mecchia Employee of: MSD Italia

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